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The Emerging Role of Lymphocyte Activation Gene 3 in the Cancer Immunotherapy

Xue Cui1,2, Min Peng2, Honglei Chen1,*

1 Department of Pathology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China
2 Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, 430060, China

* Corresponding Author: Honglei Chen. Email: email

(This article belongs to this Special Issue: Cancer Immunotherapy)

Oncologie 2022, 24(4), 665-678. https://doi.org/10.32604/oncologie.2022.023641

Abstract

The emergence of tumor immunotherapy, especially immune checkpoint inhibitors (ICIs), has brought new life to cancer treatment, and ICIs can effectively treat various tumors. Among the immune anti-cancer therapies, PD-1 is undoubtedly the hot target after CTLA-4, but due to the ineffectiveness of PD-1 in treating certain tumors, researchers have shifted their focus to other combination targets, such as LAG-3, TIM3, IDO-1, etc. One of these promising targets is LAG-3, a target with multiple clinical trials, which has increasingly shown to be an inhibitory co-receptor that plays a vital role in autoimmunity, cancer immunity, and anti-infection immunity. Immune combination therapy with LAG-3 is a hot topic, but its limitations in clinical application are also evident. This review briefly describes the molecular structure, biological functions of LAG-3 in the immune cells and cancer cells and prognosis significance, and then an overview of relevant ongoing clinical trials.

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Cite This Article

Cui, X., Peng, M., Chen, H. (2022). The Emerging Role of Lymphocyte Activation Gene 3 in the Cancer Immunotherapy. Oncologie, 24(4), 665–678.



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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