Open Access
ARTICLE
PAQR3 Inhibits the Proliferation and Tumorigenesis in Esophageal Cancer Cells
Fang Zhou*1, Shunchang Wang†1, Jianjun Wang*
* Department of Oncology, Huaihe Hospital of Henan University, Kaifeng, P.R. China
† Department of Surgery, Huaihe Hospital of Henan University, Kaifeng, P.R. China
1
These authors provided equal contribution to this work.
Oncology Research 2017, 25(5), 663-671. https://doi.org/10.3727/096504016X14761384026719
Abstract
Progestin and adipoQ receptor family member III (PAQR3), a member of the PAQR family, is frequently
downregulated in different types of human cancer. However, its expression and functions in esophageal cancer
are still unknown. This study aimed to explore the expression of PAQR3 in esophageal cancer cell lines and
to investigate the role of PAQR3 in the development of esophageal cancer. Our data showed that PAQR3 is
expressed in low amounts in human esophageal cancer cell lines. Overexpression of PAQR3 significantly suppressed the proliferation, migration, and invasion of esophageal cancer cells. In addition, overexpression of
PAQR3 downregulated the protein expression levels of RAF1, p-MEK1, and p-ERK1/2 in esophageal cancer
cells. Furthermore, overexpression of PAQR3 attenuated the tumor growth in a tumor xenograft model. In
conclusion, we demonstrated that overexpression of PAQR3 suppresses cell proliferation, migration, and invasion in esophageal cancer in vitro and in vivo. Therefore, PAQR3 may act as a therapeutic target for human
esophageal cancer.
Keywords
Cite This Article
APA Style
Zhou, F., Wang, S., Wang, J. (2017). PAQR3 inhibits the proliferation and tumorigenesis in esophageal cancer cells. Oncology Research, 25(5), 663-671. https://doi.org/10.3727/096504016X14761384026719
Vancouver Style
Zhou F, Wang S, Wang J. PAQR3 inhibits the proliferation and tumorigenesis in esophageal cancer cells. Oncol Res. 2017;25(5):663-671 https://doi.org/10.3727/096504016X14761384026719
IEEE Style
F. Zhou, S. Wang, and J. Wang "PAQR3 Inhibits the Proliferation and Tumorigenesis in Esophageal Cancer Cells," Oncol. Res., vol. 25, no. 5, pp. 663-671. 2017. https://doi.org/10.3727/096504016X14761384026719