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3-Phosphoinositide Dependent Protein Kinase-1 (PDK-1) Promotes Migration and Invasion in Gastric Cancer Cells Through Activating the NF-κB Pathway

Ning Wu*, Changyu He, Bohui Zhu*, Jinling Jiang, Yiwen Chen*, Tao Ma

* Department of Oncology, Shanghai Pudong New Area Gongli Hospital, Shanghai, P.R. China
† Department of Oncology, Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China

Oncology Research 2017, 25(7), 1153-1159. https://doi.org/10.3727/096504017X14845839228545

14 June 2024 Editors Note:

Readers are alerted that concerns were raised about the integrity of some of the data presented in the article. Further editorial action will be taken once this matter has been resolved.

Abstract

Gastric cancer (GC) is one of the most common cancers and the second leading cause of cancer deaths in the world. Many factors have been reported regarding the progression and development of GC. In this study, we aimed to investigate the correlation of 3-phosphoinositide dependent protein kinase-1 (PDK-1) with cell viability, migration, and invasion of GC. The expression of PDK-1 was measured in different GC cell lines. Thereafter, the expression of PDK-1 was interfered by small hairpin RNA (shRNA) and then incubated with or without the inhibitor of nuclear factor-kB (NF-kB) pyrrolidine dithiocarbamate (PDTC). We then investigated the effects of PDK-1 aberrant expression on GC cell viability, migration, invasion, and the epithelial– mesenchymal transition (EMT) progress. The results showed that PDK-1 was highly expressed in GC cells, and PDK-1 promoted cell viability, migration, invasion, and EMT in GC. Moreover, we confirmed that PDK-1 activated the phosphatidylinositol 3-hydroxy kinase (PI3K)/AKT and NF-kB signaling pathways. However, administration of PDTC reversed the effects of overexpression of PDK-1 on cell migration and invasion. All these findings suggest that PDK-1 may be involved in progression of GC and could be a new therapeutic target for this disease.

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Cite This Article

APA Style
Wu, N., He, C., Zhu, B., Jiang, J., Chen, Y. et al. (2017). 3-phosphoinositide dependent protein kinase-1 (PDK-1) promotes migration and invasion in gastric cancer cells through activating the NF-κB pathway. Oncology Research, 25(7), 1153-1159. https://doi.org/10.3727/096504017X14845839228545
Vancouver Style
Wu N, He C, Zhu B, Jiang J, Chen Y, Ma T. 3-phosphoinositide dependent protein kinase-1 (PDK-1) promotes migration and invasion in gastric cancer cells through activating the NF-κB pathway. Oncol Res. 2017;25(7):1153-1159 https://doi.org/10.3727/096504017X14845839228545
IEEE Style
N. Wu, C. He, B. Zhu, J. Jiang, Y. Chen, and T. Ma "3-Phosphoinositide Dependent Protein Kinase-1 (PDK-1) Promotes Migration and Invasion in Gastric Cancer Cells Through Activating the NF-κB Pathway," Oncol. Res., vol. 25, no. 7, pp. 1153-1159. 2017. https://doi.org/10.3727/096504017X14845839228545



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