Table of Content

Open Access iconOpen Access

ARTICLE

Swainsonine Inhibits Invasion and the EMT Process in Esophageal Carcinoma Cells by Targeting Twist1

Junxun Ma, Lijie Wang, Jinyu Li, Guoqing Zhang, Haitao Tao, Xiaoyan Li, Danyang Sun, Yi Hu

Department of Medical Oncology, Chinese PLA General Hospital, Beijing, P.R. China

Oncology Research 2018, 26(8), 1207-1213. https://doi.org/10.3727/096504017X15046134836575

31 July 2024 Editors Note:

Readers are alerted that concerns were raised about the integrity of some of the data presented in the article. Further editorial action will be taken once this matter has been resolved.

Abstract

Esophageal cancer is a common gastrointestinal cancer, with a very high mortality rate in patients with metastasis. Swainsonine, a cytotoxic fungal alkaloid, has been shown to inhibit cell growth in esophageal cancer. In the present study, we explored the effects of swainsonine on cell invasion and metastasis in esophageal cancer cells. Human esophageal carcinoma cells were treated with different doses of swainsonine, and then cell viability, invasion, and apoptosis were measured. The mRNA and protein expressions of Twist1, apoptosis- and EMT-related factors, and PI3K/AKT pathway factors were detected by qRT-PCR and Western blot. Swainsonine had no effect on esophageal cancer cell viability and apoptosis, but it significantly decreased cell invasion in a dose-dependent manner. Swainsonine increased the expression of E-cadherin but decreased the expression of N-cadherin, vimentin, ZEB1, and snail in a dose-dependent manner, thereby inhibiting EMT. Last, we found that swainsonine inhibits cell invasion and EMT in the esophageal carcinoma cells by downregulation of Twist1 and deactivation of the PI3K/AKT signaling pathway.

Keywords


Cite This Article

APA Style
Ma, J., Wang, L., Li, J., Zhang, G., Tao, H. et al. (2018). Swainsonine inhibits invasion and the EMT process in esophageal carcinoma cells by targeting twist1. Oncology Research, 26(8), 1207-1213. https://doi.org/10.3727/096504017X15046134836575
Vancouver Style
Ma J, Wang L, Li J, Zhang G, Tao H, Li X, et al. Swainsonine inhibits invasion and the EMT process in esophageal carcinoma cells by targeting twist1. Oncol Res. 2018;26(8):1207-1213 https://doi.org/10.3727/096504017X15046134836575
IEEE Style
J. Ma et al., “Swainsonine Inhibits Invasion and the EMT Process in Esophageal Carcinoma Cells by Targeting Twist1,” Oncol. Res., vol. 26, no. 8, pp. 1207-1213, 2018. https://doi.org/10.3727/096504017X15046134836575



cc Copyright © 2018 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 147

    View

  • 99

    Download

  • 0

    Like

Share Link