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Excellent Early Outcomes of Combined Chemotherapy With Arsenic Trioxide for Stage 4/M Neuroblastoma in Children: A Multicenter Nonrandomized Controlled Trial

Chunmou Li*1, Xiaomin Peng*1, Chuchu Feng*1, Xilin Xiong*, Jianxin Li, Ning Liao, Zhen Yang§, Aiguo Liu, Pingping Wu*, Xuehong Liang, Yunyan He, Xin Tian§, Yunbi Lin§, Songmi Wang, Yang Li*

* Pediatric Hematology/Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P.R. China
† Department of Hematology and Oncology, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, P.R. China
‡ Department of Pediatrics, The First Affiliated Hospital of GuangXi Medical University, Nanning, P.R. China
§ Department of Hematology, Kunming Children’s Hospital, Kunming, P.R. China
¶ Department of Pediatric Hematology & Oncology, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, P.R. China

Oncology Research 2020, 28(7-8), 791-800. https://doi.org/10.3727/096504021X16184815905096

Abstract

This nonrandomized, multicenter cohort, open-label clinical trial evaluated the efficacy and safety of combined chemotherapy with arsenic trioxide (ATO) in children with stage 4/M neuroblastoma (NB). We enrolled patients who were newly diagnosed with NB and assessed as stage 4/M and received either traditional chemotherapy or ATO combined with chemotherapy according to their own wishes. Twenty-two patients were enrolled in the trial group (ATO combined with chemotherapy), and 13 patients were enrolled in the control group (traditional chemotherapy). Objective response rate (ORR) at 4 weeks after completing induction chemotherapy was defined as the main outcome, and adverse events were monitored and graded in the meantime. Data cutoff date was December 31, 2019. Finally, we found that patients who received ATO combined with chemotherapy had a significantly higher response rate than those who were treated with traditional chemotherapy (ORR: 86.36% vs. 46.16%, p = 0.020). Reversible cardiotoxicity was just observed in three patients who were treated with ATO, and no other differential adverse events were observed between the two groups. ATO combined with chemotherapy can significantly improve end-induction response in high-risk NB, and our novel regimen is well tolerated in pediatric patients. These results highlight the superiority of chemotherapy with ATO, which creates new opportunity for prolonging survival. In addition, this treatment protocol minimizes therapeutic costs compared with anti-GD2 therapy, MIBG, and proton therapy and can decrease the burden to families and society. However, we also need to evaluate more cases to consolidate our conclusion.

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APA Style
Li, C., Peng, X., Feng, C., Xiong, X., Li, J. et al. (2020). Excellent early outcomes of combined chemotherapy with arsenic trioxide for stage 4/M neuroblastoma in children: A multicenter nonrandomized controlled trial. Oncology Research, 28(7-8), 791-800. https://doi.org/10.3727/096504021X16184815905096
Vancouver Style
Li C, Peng X, Feng C, Xiong X, Li J, Liao N, et al. Excellent early outcomes of combined chemotherapy with arsenic trioxide for stage 4/M neuroblastoma in children: A multicenter nonrandomized controlled trial. Oncol Res. 2020;28(7-8):791-800 https://doi.org/10.3727/096504021X16184815905096
IEEE Style
C. Li et al., "Excellent Early Outcomes of Combined Chemotherapy With Arsenic Trioxide for Stage 4/M Neuroblastoma in Children: A Multicenter Nonrandomized Controlled Trial," Oncol. Res., vol. 28, no. 7-8, pp. 791-800. 2020. https://doi.org/10.3727/096504021X16184815905096



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