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The remodeling roles of lipid metabolism in colorectal cancer cells and immune microenvironment

JIATENG ZHONG1,2, JINGYU GUO1, XINYU ZHANG1, SHUANG FENG1, WENYU DI2, YANLING WANG3,*, HUIFANG ZHU1,*

1 Department of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, 453003, China
2 Department of Pathology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453100, China
3 Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China

* Corresponding Authors: Huifang Zhu, email; Yanling Wang, email

Oncology Research 2022, 30(5), 231-242. https://doi.org/10.32604/or.2022.027900

Abstract

Lipid is a key component of plasma membrane, which plays an important role in the regulation of various cell biological behaviors, including cell proliferation, growth, differentiation and intracellular signal transduction. Studies have shown that abnormal lipid metabolism is involved in many malignant processes, including colorectal cancer (CRC). Lipid metabolism in CRC cells can be regulated not only by intracellular signals, but also by various components in the tumor microenvironment, including various cells, cytokines, DNA, RNA, and nutrients including lipids. In contrast, abnormal lipid metabolism provides energy and nutrition support for abnormal malignant growth and distal metastasis of CRC cells. In this review, we highlight the remodeling roles of lipid metabolism crosstalk between the CRC cells and the components of tumor microenvironment.

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APA Style
ZHONG, J., GUO, J., ZHANG, X., FENG, S., DI, W. et al. (2022). The remodeling roles of lipid metabolism in colorectal cancer cells and immune microenvironment. Oncology Research, 30(5), 231-242. https://doi.org/10.32604/or.2022.027900
Vancouver Style
ZHONG J, GUO J, ZHANG X, FENG S, DI W, WANG Y, et al. The remodeling roles of lipid metabolism in colorectal cancer cells and immune microenvironment. Oncol Res. 2022;30(5):231-242 https://doi.org/10.32604/or.2022.027900
IEEE Style
J. ZHONG et al., "The remodeling roles of lipid metabolism in colorectal cancer cells and immune microenvironment," Oncol. Res., vol. 30, no. 5, pp. 231-242. 2022. https://doi.org/10.32604/or.2022.027900



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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