Zhuoxi Feng^#,1, Jinyang Liu^#,2, Zihao Wu¹, Ziran Geng¹, Zhimin Liu^1,*

Congenital Heart Disease, DOI:10.32604/chd.2025.069214

Abstract Congenitally corrected transposition of the great arteries (CCTGA) is a rare congenital heart disease characterized by atrioventricular, ventriculoarterial, and conduction system discordance, commonly accompanied by atrioventricular block (AVB). Pacing in patients with CCTGA and AVB (both pediatric and adult) poses challenges in strategy selection, procedural complexity, and clinical decision-making due to limited evidence. Conventional morphological left ventricular pacing is widely adopted but may induce ventricular dyssynchrony, heart failure, and tricuspid valve dysfunction. While cardiac resynchronization therapy serves as an upgrade for pacing-induced cardiomyopathy and heart failure, its application may be limited by coronary sinus anatomical… More >

Jun He¹, Jianli Luo¹, Yanling Wang^1,*, Dai Zhou^1,*, Shuanglin Xiang^2,*

Congenital Heart Disease, DOI:10.32604/chd.2025.071773

Abstract Pediatric congenital heart disease (CHD) pharmacotherapy faces three fundamental barriers: developmental pharmacokinetic complexity, anatomic-genetic heterogeneity, and evidence chain gaps. Traditional agents exhibit critical limitations: digoxin’s narrow therapeutic index (0.5–0.9 ng/mL) is exacerbated by ABCB1 mutations (toxicity risk increases 4.1-fold), furosemide efficacy declines by 35% in neonates due to NKCC2 immaturity, and β-blocker responses vary by CYP2D6 polymorphisms (poor metabolizers require 50–75% dose reduction). Novel strategies demonstrate transformative potential—CRISPR editing achieves 81% reversal of BMPR2-associated pulmonary vascular remodeling, metabolically matured cardiac organoids replicate adult myocardial energy metabolism for drug screening, and SGLT2 inhibitors activate triple mechanisms (calcium overload More >

Khaled Elenizi¹, Abdullah Sharaf Aldeen², Nasser Alotaibi^3,*, Nagy Fagir², Hussien Hado², Mubarak Aldossari²

Congenital Heart Disease, DOI:10.32604/chd.2025.071226

Abstract Persistent left superior vena cava (PLSVC) is a rare congenital anomaly that may complicate cardiac procedures when associated with a dilated coronary sinus (CS) and conduction disturbances. We report the case of a 27-year-old male with Wilson’s disease who presented with complete heart block. Echocardiography showed biatrial enlargement and severe CS dilation, while contrast-enhanced computed tomography (CT) confirmed PLSVC draining into the CS without a bridging vein. Anatomical constraints prevented cardiac resynchronization therapy, and dual-chamber pacemaker implantation proved technically challenging due to lead placement difficulties. This case highlights the importance of thorough preoperative assessment and More >

Dehua Wu^*, Yanxuan Shi, Weixing Wang, Jiawen Tang, Tao Zhu, Guoqing Ding

Congenital Heart Disease, DOI:10.32604/chd.2025.070946

Abstract Objective: The correlation between intraoperative blood pressure thresholds and the incidence of severe adverse postoperative outcomes in geriatric patients undergoing noncardiac surgery remains inadequately characterized. This study aims to assess the association between intraoperative hypotension (IOH) parameters—specifically blood pressure thresholds and duration—and severe adverse outcomes in geriatric patients. Methods: A retrospective evaluation was performed on 846 elderly patients who underwent non-cardiac surgical procedures at Shanghai Songjiang District Hospital in China, from 01 January 2020, to 31 December 2021. Forty-one patients meeting specific exclusion criteria were excluded from the analysis, yielding a final sample size of 805.… More >

Lanqing Qu^1,2,#, Jinbiao Zhang^1,2,#, Wei Jiang^1,2, Jiayu Zhang^1,2, Die Li¹, Wei Cheng³, Linghua Tao⁴, Hongdan Zhu⁵, Jing Li⁶, Min Xue⁷, Feng Chen⁸, Cuicui Xu⁹, Qiang Shu^1,2,*, Weize Xu^1,2,*

Congenital Heart Disease, DOI:10.32604/chd.2025.066258

Abstract Background: Congenital heart disease (CHD) is the most common congenital anomaly, but whether the COVID-19 pandemic affects its prevalence is unknown. We aimed to compare the incidence of CHD during the COVID-19 pandemic with that before the pandemic in China. Methods: This multicenter retrospective observational study involved all newborns in seven representative cities of China between 01 September 2019, and 31 December 2021. All the newborns underwent pulse oximetry monitoring combined with cardiac murmur auscultation in the first 6 h to 72 h after birth for CHD screening. We defined fetuses born in and beyond September… More >

Hande İştar^1,#,*, Buğra Harmandar¹, Melike Korkmaz Toker², Fulden Cantaş Türkiş³

Congenital Heart Disease, DOI:10.32604/chd.2025.068540

Abstract Background: The neutrophil–lymphocyte ratio (NLR) is a simple, cost-effective marker of systemic inflammation. This study aims to evaluate the association between perioperative NLR and postoperative outcomes in pediatric patients undergoing congenital heart surgery with cardiopulmonary bypass (CPB). Methods: We retrospectively reviewed 70 patients under 18 years of age who underwent surgery between 2018 and 2023. NLR was measured preoperatively and on postoperative days (POD) 0, 1, 2, 3, and 6. Receiver operating characteristic analysis identified optimal cutoffs, and associations with postoperative outcomes were assessed. Results: The preoperative NLR cutoff of 1.14 (AUC = 0.75) was associated with More >

Jae Sung Son¹, Soo-Jin Kim^2,*

Congenital Heart Disease, DOI:10.32604/chd.2025.070250

Abstract Background: Advancements in diagnostic tools, surgical techniques, and long-term management have significantly improved survival among individuals with congenital heart disease (CHD), leading to an evolving epidemiologic profile characterized by increasing procedural complexity and a growing adult CHD population. This study aimed to examine nationwide trends in CHD surgeries over a 17-year period, with a focus on temporal shifts in surgical volume, procedural complexity, and age-specific incidence. Methods: A total of 41,608 CHD surgeries and 85,417 surgical procedures performed between 2002 and 2018 were identified from a nationwide health insurance database. Temporal trends were evaluated using segmented… More >

Yifan Li^1,#, Xu Huang^2,#, Bingyu Ma³, Ling Sun¹, Shushui Wang¹, Zhiwei Zhang¹, Yumei Xie^1,*

Congenital Heart Disease, DOI:10.32604/chd.2025.068286

Abstract Objective The aim of the present study was to investigate long-term efficacy and safety of percutaneous stent implantation for residual pulmonary artery stenosis (PAS) in pediatric patients after surgical repair of complicated congenital heart diseases (CHDs). Methods All pediatric patients diagnosed with residual PAS after surgical repair of complicated CHDs between 1996 and 2020 were retrospectively enrolled in the study. Results A total of 41 patients (30 males, 11 females; median age 5.0 years, median weight 17 kg) were followed-up for a median of 7.1 years. Follow-up echocardiography results demonstrated that the target vessel diameter increased from… More >

Runzhang Liang^1,2, Haiyun Yuan^1,2, Shusheng Wen^1,2,*

Congenital Heart Disease, DOI:10.32604/chd.2025.067838

Abstract This article has no abstract. More >

Kentaro Kogawa^1,2,*, Reiji Ito², Daishi Hirano², Kenji Hoshino^1,2

Congenital Heart Disease, DOI:10.32604/chd.2025.068006

Abstract Objective: To investigate the usefulness of the descending aortic retrograde flow area to forward flow area (dAO RF) ratio using echocardiography in managing pulmonary blood flow during the perioperative period following Blalock-Thomas-Taussig shunt (BTTS) surgery. Methods: This retrospective study analyzed patient characteristics, surgical procedures, and perioperative courses. The dAO RF ratio was measured upon admission to the pediatric intensive care unit (PICU) and 12, 24, 48, and 72 h post-surgery. Blood pressure, percutaneous oxygen saturation, arterial blood gas values, and lactate levels were measured at the same time as the dAO RF ratio. Results: Seventy-one cases were… More >