Athanasios Zachariou¹, Maria Filiponi², Dimitrios Baltogiannis¹, John Giannakis¹, Fotios Dimitriadis³, Panagiota Tsounapi⁴, Atsushi Takenaka⁴, Nikolaos Sofikitis¹

Canadian Journal of Urology, Vol.24, No.6, pp. 9107-9113, 2017

Abstract Introduction: Multiple sclerosis (MS) is the commonest progressive neurological disease affecting young people. With advancing disease, management of neurogenic detrusor overactivity (NDO) based on antimuscarinics may prove inadequate and if based on botulinum toxin, may necessitate clean intermittent self-catheterization. The aim of the study was to evaluate the effectiveness of combined mirabegron and desmopressin administration in the treatment of NDO in patients with MS.
Materials and methods: Sixty patients diagnosed with MS and NDO were evaluated. All had received treatment with solifenacin 10 mg/daily for 3 months and were displeased with the results. Patients were divided in… More >

Rosa Park, Christopher Rjepaj, Kathleen Lehman, Jay D. Raman

Canadian Journal of Urology, Vol.24, No.6, pp. 9103-9106, 2017

Abstract Introduction: The Clavien-Dindo (CD) and Comprehensive Complication Index (CCI) are two grading systems that annotate adverse events following surgical procedures. We compare these two classification systems in a cohort of patients undergoing radical nephroureterectomy (RNU).
Materials and methods: The charts of 110 consecutive RNU patients were reviewed for complications occurring within 30 days of surgery. Grading by the CD classification system and values for CCI were calculated. Bivariate and multivariate analysis identified associations between perioperative variables and complications, as well as relationship to hospital length of stay.
Results: Sixty-seven men and 43 women with a median age of… More >

Masaaki Yanishi, Hidefumi Kinoshita, Takashi Yoshida, Hisanori Taniguchi, Kenji Yoshida, Takao Mishima, Yoshihiro Komai, Kaneki Yasuda, Motohiko Sugi, Tadashi Matsuda

Canadian Journal of Urology, Vol.24, No.6, pp. 9098-9102, 2017

Abstract Introduction: To evaluate safety and excellent cosmetic outcome with laparoendoscopic single-site surgery (LESS). In this study, we compared the usefulness and efficacy of LESS versus conventional laparoscopic surgery for the treatment of urachal remnants.
Materials and methods: We retrospectively reviewed the medical records of 20 consecutive patients who underwent either conventional laparoscopic surgery or LESS from January 2007 to February 2015 at Kansai Medical University Hospital. Ten patients underwent surgery using the standard laparoscopic 3-port technique, and 10 patients underwent LESS. The patients included 12 males and 8 females (mean age, 24.5 years; range, 10-68 years). The… More >

Daniel R. Jeske^1,2, Jenifer A. Linehan^3,4, Timothy G. Wilson^3,4, Mark H. Kawachi³, Kristina Wittig³, Katarzya Lamparska³, Camille Amparo³, Rosa Mejia³, Fang Lai⁵, Dimitra Georganopoulou⁵, Steven S. Smith³

Canadian Journal of Urology, Vol.24, No.6, pp. 9089-9097, 2017

Abstract Introduction: Early biochemical recurrence after prostate cancer surgery is associated with higher risk of aggressive disease and cancer specific death. Many new tests are being developed that will predict the presence of indicators of aggressive disease like early biochemical recurrence. Since recurrence occurs in less than 10% of patients treated for prostate cancer, validation of such tests will require expensive testing on large patient groups. Moreover, clinical application of the validated test requires that each new patient be tested. In this report we introduce a two-stage classifier system that minimizes the number of patients that must… More >

David E. Dawe^1,2, Salaheddin Mahmud^3,4

Canadian Journal of Urology, Vol.24, No.6, pp. 9081-9088, 2017

Abstract Introduction: During their lives, 1 in 8 men will be diagnosed with prostate cancer. Several drugs have been shown to decrease prostate cancer risk, but have not been widely used in prostate cancer prevention because of concerns about side-effects and cost-effectiveness. Statins are indicated for prevention of cardiovascular disease, have an excellent benefit to risk profile, and some studies suggest that statins may reduce the risk of prostate cancer.
Materials and methods: We performed a systematic search of Medline (Ovid), EMBASE (Ovid), and PubMed. This search informed a narrative review of the biological rationale for why statins… More >

Giancarlo Vignoli

Canadian Journal of Urology, Vol.24, No.6, pp. 9080-9080, 2017

Abstract This article has no abstract. More >

Raju Thomas

Canadian Journal of Urology, Vol.24, No.6, pp. 9076-9079, 2017

Abstract This article has no abstract. More >

Leonard G. Gomella

Canadian Journal of Urology, Vol.24, No.6, pp. 9075-9075, 2017

Abstract This article has no abstract. More >

Ting Zhang¹, Lei Ye¹, Qizhi He, Jianlong Zhu

Oncology Research, Vol.25, No.9, pp. 1665-1665, 2017, DOI:10.3727/096504017X15078984695565

Abstract Ovarian cancer is highly malignant with a gradually increasing incidence and a high mortality rate. Immunosuppression is induced in ovarian cancer, although the mechanism detail is not clear. It has been indicated that HVEM (herpesvirus entry mediator) B- and T-lymphocyte attenuator (BTLA) negatively regulates the immune responses of T lymphocytes. Here, HVEM mRNA was found to be elevated in ovarian cancer tissue samples and primary ovarian cancer cells in comparison with benign tissue samples. We then knocked down HVEM expression in an ovarian cancer cell line, OVCAR3, by lentivirus-based small hairpin RNA (shRNA). Cell Counting… More >

Dina Polosukhina^*, Harold D. Love^*†, Harold L. Moses^‡§¶#, Ethan Lee^**††, Roy Zent^{†§**‡‡}, Peter E. Clark^*‡

Oncology Research, Vol.25, No.9, pp. 1653-1664, 2017, DOI:10.3727/096504017X14992942781895

Abstract Wilms tumor (WT) is the most common renal malignancy in children and the fourth most common pediatric solid malignancy in the US. Although the mechanisms underlying the WT biology are complex, these tumors most often demonstrate activation of the canonical Wnt/β-catenin pathway. We and others have shown that constitutive activation of β-catenin restricted to the renal epithelium is sufficient to induce primitive renal epithelial tumors, which resemble human WT. Here we demonstrate that pharmacologic inhibition of β-catenin gene transcription with pyrvinium inhibits tumor growth and metastatic progression in a murine model of WT. Cellular invasion More >