Bailing Zhang^*, Genlang Chen

Journal of Intelligent Medicine and Healthcare, Vol.4, pp. 109-124, 2026, DOI:10.32604/jimh.2026.084876 - 21 July 2026

Abstract High-stakes clinical decision support (CDS) demands a property that aggregate accuracy cannot capture: a trace that a clinician who was not in the room can inspect layer by layer when the system is wrong. We argue that the way to obtain this property is to refuse to entangle the large language model (LLM) with the rest of the pipeline. We propose KRD (Knowledge–Rule–Decision), a four-component architecture that separates fact extraction, a compile-time clinical knowledge layer in the spirit of the LLM Wiki pattern of Karpathy, a rule layer of hand-written contraindications and heuristics, and a decision… More >

K. Mithra^1,*, Prem Kumar Santhanam²

Journal of Intelligent Medicine and Healthcare, Vol.4, pp. 99-108, 2026, DOI:10.32604/jimh.2026.083110 - 18 June 2026

Abstract Objective: To develop a low-cost automated cataract severity classification system operating on standard consumer-grade colour photographs of the eye, without specialised ophthalmic hardware. Methods: A hybrid framework was designed that fuses deep features from a Convolutional Neural Network (CNN) with five handcrafted Grey-Level Co-occurrence Matrix (GLCM) and intensity descriptors—mean intensity, uniformity, standard deviation, contrast, and energy—extracted from a Hough-circle-localised pupil Region of Interest (ROI). A multi-class Support Vector Machine (SVM) with Radial Basis Function (RBF) kernel classifies each image into one of four severity grades: normal, immature, mature, or hypermature cataract. Results: The proposed fused system More >

K. Mithra^1,*, Prem Kumar Santhanam²

Journal of Intelligent Medicine and Healthcare, Vol.4, pp. 87-97, 2026, DOI:10.32604/jimh.2026.080288 - 24 April 2026

Abstract Background: Retinal fundus imaging is central to early diagnosis of sight-threatening conditions, including diabetic retinopathy, glaucoma, and retinal vein occlusion. Clinical utility is compromised by non-uniform illumination, motion blur, and low contrast—artefacts that reduce diagnostic accuracy. Effective image enhancement is a prerequisite for reliable computer-aided ophthalmic diagnosis. Methods: This paper proposes a two-stage enhancement pipeline combining luminosity correction via HSV colour space decomposition with Contrast Limited Adaptive Histogram Equalization (CLAHE) on the Value (V) channel. Validation is conducted on three publicly available benchmarks: DRIVE (40 images), STARE (20 images), and CHASEDB1 (28 images). Quantitative metrics… More >

Vaskar Chakma^1,#, Xiaolin Ju^1,#, Heling Cao², Xue Feng³, Xiaodong Ji³, Haiyan Pan^3,*, Gao Zhan^1,*

Journal of Intelligent Medicine and Healthcare, Vol.4, pp. 37-86, 2026, DOI:10.32604/jimh.2026.075201 - 23 January 2026

Abstract Wide QRS Complex Tachycardia (WCT) is a life-threatening cardiac arrhythmia requiring rapid and accurate diagnosis. Traditional manual ECG interpretation is time-consuming and subject to inter-observer variability, while existing AI models often lack the clinical interpretability necessary for trusted deployment in emergency settings. We developed CardioForest, an optimized Random Forest ensemble model, for automated WCT detection from 12-lead ECG signals. The model was trained, tested, and validated using 10-fold cross-validation on 800,000 ten-second-long 12-lead Electrocardiogram (ECG) recordings from the MIMIC-IV dataset (15.46% WCT prevalence), with comparative evaluation against XGBoost, LightGBM, and Gradient Boosting models. Performance was… More >

Vaskar Chakma^1,*, Md Jaheid Hasan Nerab¹, Abdur Rouf¹, Abu Sayed², Hossem Md Saim³, Md. Nournabi Khan³

Journal of Intelligent Medicine and Healthcare, Vol.4, pp. 1-35, 2026, DOI:10.32604/jimh.2026.074347 - 23 January 2026

Abstract Smoking continues to be a major preventable cause of death worldwide, affecting millions through damage to the heart, metabolism, liver, and kidneys. However, current medical screening methods often miss the early warning signs of smoking-related health problems, leading to late-stage diagnoses when treatment options become limited. This study presents a systematic comparative evaluation of machine learning approaches for smoking-related health risk assessment, emphasizing clinical interpretability and practical deployment over algorithmic innovation. We analyzed health screening data from 55,691 individuals, examining various health indicators including body measurements, blood tests, and demographic information. We tested three advanced… More >

Alex Kibet^*, Gilbert Langat

Journal of Intelligent Medicine and Healthcare, Vol.3, pp. 1-14, 2025, DOI:10.32604/jimh.2022.062824 - 04 April 2025

Abstract Multiple Sclerosis (MS) is a disease that disrupts the flow of information within the brain. It affects approximately 1 million people in the US. And remains incurable. MS treatments can cause side effects and impact the quality of life and even survival rates. Based on existing research studies, we investigate the risks and benefits of three treatment options based on methylprednisolone (a corticosteroid hormone medication) prescribed in (1) high-dose, (2) low-dose, or (3) no treatment. The study currently prescribes one treatment to all patients as it has been proven to be the most effective on More >

Mian Muhammad Danyal^1,2, Sarwar Shah Khan^3,4,*, Rahim Shah Khan⁵, Saifullah Jan², Naeem ur Rahman⁶

Journal of Intelligent Medicine and Healthcare, Vol.2, pp. 35-53, 2024, DOI:10.32604/jimh.2024.051340 - 08 July 2024

Abstract Multi-modality medical images are essential in healthcare as they provide valuable insights for disease diagnosis and treatment. To harness the complementary data provided by various modalities, these images are amalgamated to create a single, more informative image. This fusion process enhances the overall quality and comprehensiveness of the medical imagery, aiding healthcare professionals in making accurate diagnoses and informed treatment decisions. In this study, we propose a new hybrid pre-processing approach, Laplacian Filter + Discrete Fourier Transform (LF+DFT), to enhance medical images before fusion. The LF+DFT approach highlights key details, captures small information, and sharpens… More >

Umer Nauman¹, Yuhong Zhang², Zhihui Li³, Tong Zhen^1,3,*

Journal of Intelligent Medicine and Healthcare, Vol.2, pp. 15-34, 2024, DOI:10.32604/jimh.2024.048784 - 11 April 2024

Abstract The convergence of handheld devices and cloud-based computing has transformed how Electronic Health Records (EHRs) are stored in mobile cloud paradigms, offering benefits such as affordability, adaptability, and portability. However, it also introduces challenges regarding network security and data confidentiality, as it aims to exchange EHRs among mobile users while maintaining high levels of security. This study proposes an innovative blockchain-based solution to these issues and presents secure cloud storage for healthcare data. To provide enhanced cryptography, the proposed method combines an enhanced Blowfish encryption method with a new key generation technique called Elephant Herding… More >

Uma Ramasamy^*, Sundar Santhoshkumar

Journal of Intelligent Medicine and Healthcare, Vol.2, pp. 1-14, 2024, DOI:10.32604/jimh.2023.046995 - 10 January 2024

Abstract More than 140 autoimmune diseases have distinct autoantibodies and symptoms, and it makes it challenging to construct an appropriate model using Machine Learning (ML) for autoimmune disease. Arthritis-related autoimmunity requires special attention. Although many conventional biomarkers for arthritis have been established, more biomarkers of arthritis autoimmune diseases remain to be identified. This review focuses on the research conducted using data obtained from clinical laboratory testing of real-time arthritis patients. The collected data is labelled the Arthritis Profile Data (APD) dataset. The APD dataset is the retrospective data with many missing values. We undertook a comprehensive… More >

Colleen Crangle^1,2,*, Bude Piccin², Lara Hyde³, Elin Östman⁴

Journal of Intelligent Medicine and Healthcare, Vol.1, No.2, pp. 91-102, 2022, DOI:10.32604/jimh.2022.038379 - 05 January 2023

Abstract Postprandial glucose responses provide vital information on an individual’s risk of major diet-related chronic diseases. This study features digital health technology, namely Continuous Glucose Monitoring (CGM) sensors, along with mobile devices (iPhones running an app) used to collect data from individuals and their environment, specifically nutritional information on what they eat and drink. The paper presents a retrospective analysis of data collected during an investigation into the use of a functional drink taken as a supplement with a standardized meal to reduce postprandial responses to that meal. Given that there are consequential differences between individuals… More >