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    ARTICLE

    Anti-lipid droplets accumulation effect of Annona montana (mountain soursop) leaves extract on differentiation of preadipocytes

    IVY LEUNG1, MARIA-LUISA VEISAGA2, MARGARITA ESPINAL1, WEI ZHANG1, ROBERT BARNUM1, MANUEL ALEJANDRO BARBIERI1,2,3,4,*

    BIOCELL, Vol.46, No.3, pp. 567-578, 2022, DOI:10.32604/biocell.2022.014009

    Abstract The Annona genus is a member of Annonaceae, one of the largest families of plants across tropical and sub-tropical regions. This family has been used in several ethnomedicinal practices to treat a multitude of human diseases. However, the molecular mechanism underlying its effect on the lipid droplet formation and on the expression of adipogenic markers of this plant remain to be investigated. In this study, we examined whether the extracts from the aerial part of Annona montana affect in vitro differentiation of preadipocytes. For our investigations, both mouse embryo fibroblast 3T3-L1 and normal human primary subcutaneous preadipocytes were incubated with… More >

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