CARLOS ALBERTO-SILVA1,*, ANA CAROLINA DE ARAUJO1, RODRIGO SIMãO BONFIM1, JOYCE MEIRE GILIO2
BIOCELL, Vol.47, No.2, pp. 289-295, 2023, DOI:10.32604/biocell.2023.023787
Abstract Bothrops envenomation is complex and provokes prominent local tissue damage and systemic disturbances, but little is known about their effects on the male reproductive system. After intratesticular injection, the bioactive peptide fraction (Bj-PF) obtained from Bothrops jararaca snake venom changes the structure of different stages of the seminiferous epithelium cycle in adult mice. For the first time, we investigated whether local envenomation of Bj-PF induces toxicological effects on the male reproductive system, particularly on the seminiferous epithelium and Sertoli cells. Male adult mice were treated with 0.24 mg.kg−1 by intramuscular (i.m.) injection for 24 h. The testes samples were collected… More >
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