MENGDAN WU1, MENGYAO SUN1, QINHUAI LAI1, YIN LU1, YUYIN FU1, YUJIA PENG1, WEIRONG LAI1, LISHI ZENG1, SHENGYAN ZHAO1, YUYAN LI1, ZHIXIONG ZHANG1, XIAOFENG CHEN1, FAN QIAO1, YIWEN ZHANG1,*, SHIJIE ZHOU1,2,*, LANTU GOU1, JINLIANG YANG1,2
BIOCELL, Vol.45, No.3, pp. 589-597, 2021, DOI:10.32604/biocell.2021.013882
Abstract The chemokine ligand 13-chemokine receptor 5 (CXCL13-CXCR5) axis has been characterized as a critical
tumor-promoting signaling pathway in the tumor microenvironment (TME) in multiple types of solid tumors. In this
study, we analyzed the expression profile of CXCL13 in kidney clear cell carcinoma (KIRC) and its correlation with
tumor-infiltrating immune cells (TIICs). A monoclonal antibody against CXCL13 with high affinity and purity was
generated in our lab for western blot and immunohistochemistry (IHC). Bioinformatic analysis was performed based
on bulk-seq data from the Cancer Genome Atlas (TCGA)-KIRC and single-cell RNA-seq data from scRNASeqDB
and PanglaoDB. Results showed that high CXCL13… More >
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