Fariborz Soheili1,2, Zahra Jalili3, Mahtab Rahbar4, Zahed Khatooni1, Amir Mashayekhi5, Hossein Jafari6
Congenital Heart Disease, Vol.13, No.2, pp. 295-304, 2018, DOI:10.1111/chd.12571
Abstract Background: The mutations in GATA4 gene induce inherited atrial and ventricular septation
defects, which is the most frequent forms of congenital heart defects (CHDs) constituting about
half of all cases.
Method: We have performed High resolution melting (HRM) mutation scanning of GATA4 coding
exons of nonsyndrome 100 patients as a case group including 39 atrial septal defects (ASD), 57
ventricular septal defects (VSD) and four patients with both above defects and 50 healthy individuals as a control group. Our samples are categorized according to their HRM graph. The genome
sequencing has been done for 15 control samples and 25 samples… More >
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