Yue Cai*†‡, Chizhi Zhang*†‡, Lei Zhan*†, Liangbin Cheng*†, Dingbo Lu*†, Xiaodong Wang*†,
Hanlin Xu§, Shuxue Wang¶, Deng Wu*†, Lianguo Ruan#
Oncology Research, Vol.27, No.8, pp. 889-899, 2019, DOI:10.3727/096504018X15482423944678
Abstract The thorns of Gleditsia sinensis have been historically used in Chinese medicine and are considered one of the
fundamental therapeutic herbs. Its anticancer effects are currently being explored. Hepatocellular carcinoma
(HCC) is the most common type of primary liver cancer and still requires the development of new drugs with
higher efficiency. By using a rat HCC model implanted with cancerous Walker-256 cells, the therapeutic effects
of G. sinensis extract (GSE) were assessed, as well as its regulatory effects on miRNAs. GSE significantly
restored liver morphology and dramatically induced cell apoptosis in HCC rats. In addition, miR-21/181b/183
was upregulated in the… More >
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