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    In vivo Effects of Aqueous Extract of Gongronema latifolium Benth on the Tumor Necrosis Factor-α, Transforming Growth Factor-β, and Hepatic Enzymes

    Adekunle Babajide Rowaiye1,2, Moses Okonkwo Njoku3, Angus Nnamdi Oli2, Sousan Akrami4,5, Titilayo Asala1, Ikemefuna Chijioke Uzochukwu6, Alex Akpa1, Morteza Saki4,5,*, Charles Okechukwu Esimone2

    Oncologie, Vol.23, No.4, pp. 547-557, 2021, DOI:10.32604/oncologie.2021.019738

    Abstract Nonsteroidal anti-inflammatory drugs have a number of side effects. However, some medicinal herbs have anti-inflammatory properties with few side effects. This study aimed to determine the effect of the aqueous extract of Gongronema latifolium (AEGL) leaves on the level of tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in rabbits. Enzyme-linked immunosorbent assay (ELISA) was performed to determine the effect of the AEGL on the activities of pro-inflammatory cytokine (TNFα), and regulatory cytokine (TGF-β) in rabbits. Also, a colorimetric method was performed to evaluate the levels of AST and More >

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