SILVIA S. BORKOSKY1,2, HITOSHI NAGATSUKA1, YORIHISA ORITA3, HIDETSUGU TSUJIGIWA4, JUNKO YOSHINOBU3, MEHMET GUNDUZ1, ANDREA P. RODRIGUEZ1, LILIANA R. MISSANA2, KAZUNORI NISHIZAKI3, NORIYUKI NAGAI1
BIOCELL, Vol.32, No.3, pp. 251-257, 2008, DOI:10.32604/biocell.2008.32.251
Abstract The Notch signaling pathway is an evolutionary conserved mechanism that plays an important role in cell-cell communication and cell fate in a wide range of tissues. The mammalian family of Notch receptors consists of 4 members: Notch1/2/3/4. The Notch ligand family consists of 5 members: Delta1/3/4 and Jagged1/2. Math1 encodes a murine basic helix-loop-helix (bHLH) transcription factor that acts as positive regulator of cell differentiation. Recently, links between Notch and Math1 pathways were demonstrated in various tissues. Expression of Notch1, Jagged2 and Math1 were analyzed in the mouse molar tooth germ during embryonic stage (E) 13 and E15 and during… More >
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