Andrea Lapucci*†1, Gabriele Perrone*†1, Antonello Di Paolo‡§, Cristina Napoli*†, Ida Landini*†,
Giandomenico Roviello*†, Laura Calosi¶, Antonio Giuseppe Naccarato#, Alfredo Falcone#, Daniele Bani¶, Enrico Mini*†§2, Stefania Nobili*†§2,3
Oncology Research, Vol.28, No.6, pp. 631-644, 2020, DOI:10.3727/096504020X16056983169118
Abstract The benefit of adjuvant chemotherapy in the early stages of colorectal cancer (CRC) is still disappointing and
the prediction of treatment outcome quite difficult. Recently, through a transcriptomic approach, we evidenced
a role of PNN and KCNQ1OT1 gene expression in predicting response to fluoropyrimidine-based adjuvant
chemotherapy in stage III CRC patients. Thus, the aim of this study was to validate in an independent cohort of
stages II–III CRC patients our previous findings. PNN and KCNQ1OT1 mRNA expression levels were evaluated in 74 formalin-fixed paraffin-embedded tumor and matched normal mucosa samples obtained by stages
II–III CRC patients treated with fluoropyrimidine-based adjuvant… More >
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