ABDUR RAUF1,*, SAUD BAWAZEER2,*, MUSLIM RAZA3, EMAN EL-SHARKAWY4, MD. HABIBUR RAHMAN5,6, MOHAMED A. EL-ESAWI7, GHIAS UDDIN8, BINA S. SIDDIQUI9, ANEES AHMED KHALIL10, JOSEPH MOLNAR11, AKOS CSONKA11, DIÁNA SZABÓ12, HAROON KHAN13, MOHAMMAD S. MUBARAK14, TAIBI BEN HADDA15, MUDYAWATI KAMARUDDIN16, SEEMA PATEL17
BIOCELL, Vol.45, No.1, pp. 139-147, 2021, DOI:10.32604/biocell.2021.013277
Abstract The bioactive triterpenoid 3-oxo-6-β-hydroxy-β-amyrin (1) has been isolated from multiple plant sources. In this
study, chloroform fraction of Pistacia integerrima extract was processed for the isolation of the compound. The compound
identity was confirmed by advanced spectroscopy technique. X-ray crystallography was applied for molecular structure
confirmation. In addition, compound 1 was screen for its activity on reversal of MDR (multidrug resistance) mediated
by P-gp (P-glycoprotein). This was accomplished by using rhodamine123 exclusion on multidrug-resistant human
ABCB1 gene transfected mouse T-lymphoma cell line. Outcomes revealed that MDR reversing effect was comparable to
verapamil as positive control in vitro. Treatment of TPA-induced… More >
Login
Register
