JIYU WANG#, YING PAN#, YANG WAN, ZHIXIANG WANYAN, ZHITAO WANG, QIANSHAN TAO, ZHIMIN ZHAI*
BIOCELL, Vol.45, No.4, pp. 933-942, 2021, DOI:10.32604/biocell.2021.014280
Abstract The present study aimed to clarify the role of SENEX in malignant cell proliferation in diffuse large B-cell
lymphoma (DLBCL). 22 DLBCL patients (6 newly diagnosed cases, 7 cases at complete remission, and 9 relapsed
cases) were included in the study. Our results indicated that both SENEX gene and protein were significantly
increased in peripheral blood mononuclear cells (PBMCs) and tumor cells of relapsed DLBCL patients, accompanied
by overexpression of p21, p16, and phosphorylated retinoblastoma (Rb). Silencing the SENEX gene in a DLBCL cell
line caused a significant decrease in cell proliferation and inhibited cell cycle progression in the G1… More >
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