Lifen Zheng1, Fangfang Chen2, Yuanjun Li3, Changfu Li1,*
Phyton-International Journal of Experimental Botany, Vol.91, No.5, pp. 989-998, 2022, DOI:10.32604/phyton.2022.019219
Abstract 8,12-sesquiterpene lactones (STLs) are an important class of natural products with unique pharmaceutical activities. For years the pathway leading to 8,12-STLs remains an enigma. Xanthium strumarium accumulates abundant 8,12-STLs, and xanthatin is a characteristic 8,12-STL in it. Xanthatin has been previously postulated to be derived from germacrene A, but the steps from germacrene A to xanthatin are unknown. As part of an effort to understand the xanthatin biosynthetic pathway. This study reports the characterization of a unique germacrene A oxidase (XsGAO) from X. strumarium. Unlike a classical GAO enzyme, which is known to catalyze a three-step oxidation of germarene A… More >
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