HANXIANZHI XIAO, RONGJIA QI, ZILING WANG, MINGHE XIAO, YUE XIANG, YAPING WANG, LU WANG*
BIOCELL, Vol.45, No.4, pp. 1045-1058, 2021, DOI:10.32604/biocell.2021.015039
Abstract Chemotherapy may cause cellular oxidative stress to bone marrow. Oxidative damage of bone marrow
hematopoietic microenvironment is closely related to chronic myelosuppression after chemotherapeutic treatment.
Angelica sinensis polysaccharides (ASP) are major effective ingredients of traditional Chinese medicine Angelica with
multi-target anti-oxidative stress features. In the current study, we investigated the protective roles and mechanisms
of ASP on chemotherapy-induced bone marrow stromal cell (BMSC) damage. The human bone marrow stromal cell
line HS-5 cells were divided into control group, 5-FU group, 5-FU + ASP group, and 5-FU + LiCl group to
investigate the mechanism of ASP to alleviate 5-FU-induced BMSC proliferation… More >
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