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    ARTICLE

    Application of the Principles of “Green Chemistry” for the Synthesis of 10-Undecylenic Aliphatic Esters with Antimicrobial Activity

    Dragomir Vassilev1,*, Nadezhda Petkova2, Yulian Tumbarski3, Milena Koleva1, Panteley Denev2

    Journal of Renewable Materials, Vol.8, No.6, pp. 675-686, 2020, DOI:10.32604/jrm.2020.09279

    Abstract Undenicylic acid (10:1) is known as an antifungal agent and an active ingredient of many topical medicines [1–6]. The present research investigates the preparation of aliphatic esters of 10-undecylic acid with butanol and i-amyl alcohol by the conventional and ultrasound-assisted syntheses as well as the structural elucidation of the resulting compounds, by FTIR and NMR spectroscopy. The antimicrobial properties of the obtained 10-undecylenic esters were tested against Gram-positive bacteria (Staphylococcus aureus; Enterococcus faecalis; Listeria monocytogenes), Gram-negative bacteria (Escherichia coli; Salmonella sp.) and filamentous fungi (Penicillium sp.; Aspergillus niger; Fusarium moniliforme) using the conventional agar-well diffusion assay. The results demonstrated that… More >

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