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  • Open Access

    PROCEEDINGS

    Research on the Synergistic Mechanism of Photothermal-Chemotherapy-Immunotherapy of Multi-Functional Nanoparticles Against Gastric Cancer

    Erdong Shen1, Ting Pan1, Pan Guo1, Ke Chen1, Rui Xu1, Mei Yang1, Dahe Zhan1, Fang Fang1, Qinghui Wu1,*, Jianbing Hu1,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.4, pp. 1-3, 2024, DOI:10.32604/icces.2024.012772

    Abstract Objective
    This study investigates the synergistic effects of a novel multifunctional nanoparticle on gastric cancer treatment through photothermal therapy, chemotherapy, and immunotherapy.

    Method
    Synthesize hollow mesoporous Prussian blue nanoparticles and load them with luteolin. Use exosomes to encapsulate the nanoparticles and modify the surface of the targeted peptide GX1. Detect the morphology of nanoparticles using a nanoparticle size analyzer and transmission electron microscopy. Use Coomassie Brilliant Blue to detect the effect of extracellular vesicle encapsulation. Detect the thermal conversion efficiency of nanoparticles under specific laser irradiation through infrared and ultraviolet spectroscopy, as well as the release rate… More >

  • Open Access

    PROCEEDINGS

    Multiscale Mechanics Design of Biodegradable Nano-Architected Materials: Toward a Sustainable Future

    Yuanzhen Hou1, YinBo Zhu1, Heng-an Wu1,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.4, pp. 1-2, 2024, DOI:10.32604/icces.2024.011353

    Abstract Traditional materials are emerging increasingly severe problems such as environmental pollution, non-renewability, and resource waste. As the most abundant natural biomass in nature, nanocellulose materials are expected to become a new generation of green, biodegradable, high-performance structural materials and contribute to sustainable development. Starting from the intrinsic relationship between hydrogen bonding network and microstructure deformation in nanocellulose, we performs the bottom-up multiscale mechanics methods, combing theoretical modeling, experimental characterization and material preparation, to reveal the physical mechanism and key characteristic parameters of the microstructure-regulated mechanical behaviors of nanocellulose materials, further establishing the cross-scale relationship between… More >

  • Open Access

    PROCEEDINGS

    Progressive Damage Analysis of 3D Woven Composite SENT Test Using a Ternary Model

    Wushuai Liu1, Wu Xu1,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.3, pp. 1-1, 2024, DOI:10.32604/icces.2024.012893

    Abstract It is of great significance for improving the in-plane fracture toughness of 3D woven composite (3DWC) to study the failure mechanism of a single edge notch tension (SENT) test. It requires a relatively high computational cost to establish the SENT model based on conformal modeling method. A SENT is established using a proposed ternary model. The matrix cracking, yarn rupture, and debonding at the yarn/matrix interface are involved in the ternary model. Based on the developed SENT model, the progressive damage initiation and evolution of 3DWC SENT are predicted. The load-displacement curves and damage of More >

  • Open Access

    PROCEEDINGS

    Mechanisms of Thermo-Mechanical Fatigue Crack Growth in a Polycrystalline Ni-Base Superalloy

    Lu Zhang1,*, Yuzhuo Wang1, Zhiwei Yu1, Rong Jiang1, Liguo Zhao1, Yingdong Song1,2

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.3, pp. 1-2, 2024, DOI:10.32604/icces.2024.012701

    Abstract Thermo-mechanical fatigue (TMF), as the main failure mode of hot components of an aeroengine, are increasingly investigated recently [1,2]. TMF crack growth is studied in a nickel-based powder metallurgy (PM) superalloy subjected to in-phase (IP) and out-of-phase (OP), as well as isothermal fatigue (IF) at peak temperature. The crack growth rate and path are evaluated for both coarse grain (CG) and fine grain (FG) structure, especially the effects of phase angle and polycrystalline microstructure. The results show that the TMF crack propagation is mainly transgranular in OP condition; while in IP condition, crack propagates intergranularly… More >

  • Open Access

    PROCEEDINGS

    A Study on the Extraction and Evaluation Method of Virtual Strain

    Peiyan Wang1,*, Haoyu Wang1, Minghui Liu2, Fuchao Liu1, Zhufeng Yue1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.3, pp. 1-1, 2024, DOI:10.32604/icces.2024.011318

    Abstract The virtual test is supported by the physical test data, and a high-precision simulation model needs to be established to maximize the alignment between the simulation prediction results and the physical test data. It can replace other physical tests and achieve the goal of reducing the design cycle time and cost. However, due to the errors caused by the position and angle deviation of the strain gauge paste, as well as the sensitivity coefficient of the strain gauge and the wire, it is difficult for the simulation results to correspond to the test results in… More >

  • Open Access

    PROCEEDINGS

    Mechanical Properties and Failure Modes of 3D-Printed Continuous Fiber-Reinforced Single-Bolt Composite Joints with Curved Paths and Variable Hatch Spaces

    Xin Zhang1,2, Xitao Zheng1,2, Tiantian Yang3, Mingyu Song1,2, Yuanyuan Tian4, Leilei Yan1,2,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.3, pp. 1-1, 2024, DOI:10.32604/icces.2024.011277

    Abstract Composite joints are widely used in machinery industries such as aviation, aerospace, and marine, where they transfer main loads as lightweight connectors. Recently, 3D printing with continuous fibers has relieved the required molds in composite manufacturing process and given flexibility to the design of robust composite joints. However, how the curved paths and variable hatch spaces affect the mechanical properties and failure modes of 3D-printed single-bolt composite joints with continuous fibers remains undisclosed. In this study, 3D printing has been introduced to fabricate three types of continuous fiber-reinforced single-bolt composite joints with different paths, including… More >

  • Open Access

    PROCEEDINGS

    Finite Element Modelling of Composite Armor Against 7.62 mm Projectile Impact

    Lei Peng1,*, Jin Zhou2, Xianfeng Zhang3, Zhongwei Guan4,5

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.3, pp. 1-1, 2024, DOI:10.32604/icces.2024.011196

    Abstract This paper presents the numerical modelling of the ballistic response of hybrid composite structures subjected to 7.62 mm projectile impact. This study focuses on the modelling of composites made of various materials, including ceramics, Ultra-High-Molecular-Weight Polyethylene (UHMWPE), Kevlar, and compressed wood, with fabrication of hybrid laminated structures that offer promising ballistic resistance capabilities. By employing a range of constitutive models and failure criteria, the finite element model simulates the ballistic behaviors of the constituent materials, facilitating a comprehensive understanding of their performance under high-velocity impacts. The core of the study lies in the comparison between… More >

  • Open Access

    CORRECTION

    Correction: Influence of Various Earth-Retaining Walls on the Dynamic Response Comparison Based on 3D Modeling

    Muhammad Akbar1,2, Huali Pan1,*, Jiangcheng Huang3, Bilal Ahmed4, Guoqiang Ou1

    CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.3, pp. 2625-2625, 2024, DOI:10.32604/cmes.2024.059706 - 31 October 2024

    Abstract This article has no abstract. More >

  • Open Access

    EDITORIAL

    Introduction to the Special Issue on The Bottleneck of Blockchain Techniques Scalability, Security and Privacy Protection

    Shen Su1,*, Daojing He2, Neeraj Kumar3

    CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.3, pp. 1933-1937, 2024, DOI:10.32604/cmes.2024.059318 - 31 October 2024

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Parameter Optimization of Tuned Mass Damper Inerter via Adaptive Harmony Search

    Yaren Aydın1, Gebrail Bekdaş1,*, Sinan Melih Nigdeli1, Zong Woo Geem2,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.3, pp. 2471-2499, 2024, DOI:10.32604/cmes.2024.056693 - 31 October 2024

    Abstract Dynamic impacts such as wind and earthquakes cause loss of life and economic damage. To ensure safety against these effects, various measures have been taken from past to present and solutions have been developed using different technologies. Tall buildings are more susceptible to vibrations such as wind and earthquakes. Therefore, vibration control has become an important issue in civil engineering. This study optimizes tuned mass damper inerter (TMDI) using far-fault ground motion records. This study derives the optimum parameters of TMDI using the Adaptive Harmony Search algorithm. Structure displacement and total acceleration against earthquake load More >

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