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  • Open Access

    ARTICLE

    Co-expression of CCR7 and H3K9me3 identifies aggressive B-cell lymphoma with bone marrow infiltration and poor prognosis

    Jiawen Chen1,#, Zelin Liu1,#, Keke Huang1, Jinlan Li1, Yajie Zhang1, Dandan Chen1, Yanjie Ruan2, Ying Pan1, Furun An1, Yang Wan1,*, Jiyu Wang1,3,*, Qianshan Tao1,*

    European Cytokine Network, Vol.37, No.1, pp. 25-39, 2026, DOI:10.32604/ecn.2026.077875 - 13 April 2026

    Abstract Objectives: B-cell lymphoma exhibits significant clinical heterogeneity, necessitating improved biomarkers for risk stratification. C-C chemokine receptor 7 (CCR7) and trimethylation of histone H3 lysine 9 (H3K9me3) are implicated in cellular senescence and tumor invasion. While the clinical significance of their co-expression in lymphomagenesis remains unclear. This study aims to define the expression profiles of CCR7 and H3K9me3 in B-cell lymphoma, explore their correlation with aggressive clinical indicators, and evaluate their combined prognostic value. Methods: The expression of CCR7 and H3K9me3 in tumor tissues from B-cell lymphoma patients was analyzed by immunohistochemical (IHC) double-staining. The mechanistic… More >

  • Open Access

    ARTICLE

    Exploring Sustainable Smart Long-Term Care Systems Using Fuzzy Trade-Off-Aware Scoring with Conflicts Framework

    Kuen-Suan Chen1,2,3, Tsai-Sung Lin4, Ruey-Chyn Tsaur4,*, Minh T. N. Nguyen5

    CMC-Computers, Materials & Continua, Vol.87, No.3, 2026, DOI:10.32604/cmc.2026.079476 - 09 April 2026

    Abstract As artificial intelligence, the Internet of Things, edge computing, and blockchain are increasingly integrated into long-term care (LTC) services, policymakers face complex and often non-compensatory trade-offs among affordability, workforce sustainability, service reliability, and data governance. Conventional compensatory evaluation models tend to mask critical structural weaknesses and limiting their usefulness for Smart LTC policy assessment. This study proposes and applies a Fuzzy Trade-Off-Aware Scoring with Conflicts (Fuzzy TASC) framework to evaluate Smart LTC system performance. Four digital-integration configurations—conventional cloud-based LTC, AI+IoT, AI+Edge, and AI+Blockchain—were compared across 12 OECD countries. A Monte Carlo perturbation procedure was incorporated… More >

  • Open Access

    ARTICLE

    A Comprehensive Framework for Nature-Inspired Photovoltaic Model Calibration and Explainable Surrogate-Based Sensitivity Analysis

    Yan-Hao Huang*, Chung-Ming Kao

    CMC-Computers, Materials & Continua, Vol.87, No.3, 2026, DOI:10.32604/cmc.2026.079381 - 09 April 2026

    Abstract Photovoltaic (PV) equivalent-circuit models are widely used for performance evaluation and diagnostics, but their usefulness relies on both accurate calibration and interpretable understanding of how parameters shape current–voltage (I–V) behavior. For nonlinear and strongly coupled PV models, conventional global sensitivity analysis can be computationally demanding and offer limited insight into effect direction and operating-point dependence. This study presents an method-oriented framework that integrates nature-inspired optimization with surrogate-based explainable global sensitivity analysis under a specified operating condition. The Starfish Optimization Algorithm (SFOA) is first used for parameter identification by searching for the optimal parameter set that… More >

  • Open Access

    ARTICLE

    Trustworthy Personalized Federated Recommender System with Blockchain-Assisted Decentralized Reward Management

    Waqar Ali1, May Altulyan2, Ghulam Farooque3, Siyuan Li4, Jie Shao4,5,*

    CMC-Computers, Materials & Continua, Vol.87, No.3, 2026, DOI:10.32604/cmc.2026.078599 - 09 April 2026

    Abstract Federated recommender systems (FedRS) enable collaborative model training while preserving user privacy, yet they remain vulnerable to adversarial attacks, unreliable client updates, and misaligned incentives in decentralized environments. Existing approaches struggle to jointly preserve personalization, robustness, and trust when user data are highly non-IID and recommendation quality is governed by ranking-oriented objectives. To address these challenges, we propose a Trustworthy Federated Recommender System (T-FedRS) that extends federated neural collaborative filtering by integrating a ranking-aware reputation mechanism and a lightweight blockchain layer for transparent incentive allocation. Personalization is preserved through locally maintained user embeddings, while item parameters… More >

  • Open Access

    ARTICLE

    Artificial Neural Network-Based Prediction and Validation of Drill Flank Wear in GFRP Machining for Sustainable and Smart Manufacturing

    Sathish Rao Udupi, Gururaj Bolar, Manjunath Shettar*, Ashwini Bhat

    CMC-Computers, Materials & Continua, Vol.87, No.3, 2026, DOI:10.32604/cmc.2026.078574 - 09 April 2026

    Abstract Glass fiber-reinforced polymer composites (GFRPCs) are extensively utilized in the aerospace, automotive, and structural sectors; nevertheless, their heterogeneous and abrasive characteristics result in rapid tool wear during drilling. Drill flank wear among various wear mechanisms notably influences hole quality and dimensional accuracy. This research investigates the impact of spindle speed, feed rate, and drill diameter on flank wear during dry drilling of GFRPC laminates with high-speed steel (HSS) twist drills. A full-factorial design with 81 experiments is used to create a comprehensive dataset. ANOVA indicates that spindle speed is the dominant factor affecting wear changes,… More >

  • Open Access

    ARTICLE

    Edge-Intelligent Photovoltaic Fault Localization via NAS-Optimized Feature-Space Sub-Pixel Matching

    Hongjiang Wang1, Jian Yu2, Tian Zhang3, Na Ren4, Nan Zhang2, Zhenyu Liu1,*

    CMC-Computers, Materials & Continua, Vol.87, No.3, 2026, DOI:10.32604/cmc.2026.077997 - 09 April 2026

    Abstract The rapid deployment of Industrial Internet of Things (IIoT) systems, such as large-scale photovoltaic (PV) power stations in modern power grids, has created a strong demand for edge-intelligent fault localization methods that can operate reliably under strict computational and memory constraints. In this work, we propose an edge-intelligent photovoltaic fault localization framework that integrates intelligent computation with classical sub-pixel optimization. The framework adopts a modular, edge-oriented design in which a radial basis function (RBF) network is first employed as a lightweight screening module to enable conditional execution, thereby reducing unnecessary computation for non-faulty samples. For… More >

  • Open Access

    ARTICLE

    Structured Random Cycle-Guided Algorithm (SRCA): An Adaptive Metaheuristic Combining Directionally-Guided and Stochastic Search Strategies

    Giuseppe Marannano*, Antonino Cirello, Tommaso Ingrassia

    CMC-Computers, Materials & Continua, Vol.87, No.3, 2026, DOI:10.32604/cmc.2026.077884 - 09 April 2026

    Abstract In response to the growing need for adaptive optimization algorithms capable of handling complex, multimodal, and high-dimensional search spaces, this paper introduces the Structured Random Cycle-guided Algorithm (SRCA). SRCA is not presented as a fundamentally new optimization paradigm, but rather as an architectural synthesis and a unified adaptive framework for dynamic operator selection. Based on a cycle-structured architecture, directional and stochastic search behaviors are dynamically selected at the individual level. The algorithm orchestrates well-established structured movements with a diverse pool of stochastic exploration strategies, enabling a coherent and adaptive balance between exploration and exploitation throughout More >

  • Open Access

    ARTICLE

    Efficient Gait Phase Estimation and Trajectory Prediction in Wearable Devices Using a Dual-Stage Approach

    Sihan Wang1, Luyao Liu2, Xingjun Wang3,*, Yifan Liu3,*

    CMC-Computers, Materials & Continua, Vol.87, No.3, 2026, DOI:10.32604/cmc.2026.077791 - 09 April 2026

    Abstract This paper presents a novel dual-stage approach for efficient gait phase recognition and trajectory prediction, tailored for the operation of wearable devices such as exoskeletons. By leveraging dynamic template matching techniques and addressing their computational challenges, we propose an innovative algorithm that significantly enhances both prediction accuracy and computational efficiency. The approach integrates Dynamic Time Warping-KMeans (DTW-KM) template selection in the offline phase and a Soft Constraint Weighted (SCW) template matching technique in the online phase. In the offline stage, the DTW-KM method extracts diverse and generalizable gait patterns from a database, establishing a robust More >

  • Open Access

    ARTICLE

    Multi-Agent Large Language Model-Based Decision Tree Analysis for Explainable Electric Vehicle Drive Motor Fault Diagnosis

    Jaeseung Lee1, Jehyeok Rew2,*

    CMC-Computers, Materials & Continua, Vol.87, No.3, 2026, DOI:10.32604/cmc.2026.077691 - 09 April 2026

    Abstract The accelerating transition toward electrified mobility has positioned electric vehicles (EVs) as a primary technology in modern transportation systems. In this context, ensuring the reliability of EV drive motors (EVDMs) becomes increasingly critical, given their central role in propulsion performance and operational safety. Accurate and interpretable fault diagnosis of EVDMs is therefore essential for enabling effective maintenance and supporting the broader sustainability and resilience of EVs. This study presents a novel framework that combines decision tree-based fault classification with a multi-agent large language model (LLM) interpretation architecture to deliver transparent and human-readable diagnostic explanations. The… More >

  • Open Access

    ARTICLE

    Calculation Method and Simulation for Workspace of Arm–Rail Coordinated Spray Painting Robot

    Kai Li1, Guolei Wang2, Dunmin Lu1,*, Yanbin Yao3, Zhiyong Li4

    CMC-Computers, Materials & Continua, Vol.87, No.3, 2026, DOI:10.32604/cmc.2026.077651 - 09 April 2026

    Abstract To address the need for improving the efficiency of spray painting large and complex curved surfaces, this study investigates the arm–rail coordinated spray painting operation method and proposes a robot workspace calculation method for efficient spray area partitioning. The steps for calculating the workspace under the constraints of the principal normal vector and the conical pose domain are introduced, along with an analysis of the robot’s forward and inverse kinematics. Simulation validation was conducted using a wind turbine blade as the target object. The results show that the workspace based on conical pose domain constraints More >

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