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    Coarse-grained Modeling and Simulation of Actin Filament Behavior Based on Brownian Dynamics Method

    Yoshitaka Shimada∗,†, Taiji Adachi∗,†,‡, Yasuhiro Inoue∗,†, Masaki Hojo

    Molecular & Cellular Biomechanics, Vol.6, No.3, pp. 161-174, 2009, DOI:10.3970/mcb.2009.006.161

    Abstract The actin filament, which is the most abundant component of the cytoskeleton, plays important roles in fundamental cellular activities such as shape determination, cell motility, and mechanosensing. In each activity, the actin filament dynamically changes its structure by polymerization, depolymerization, and severing. These phenomena occur on the scales ranging from the dynamics of actin molecules to filament structural changes with its deformation due to the various forces, for example, by the membrane and solvent. To better understand the actin filament dynamics, it is important to focus on these scales and develop its mathematical model. Thus,… More >

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