KSENIJA VELICKOVIC1,2,#, HILDA ANAID LUGO LEIJA1,3,#, SARAH MCGINLAY1,3,#, MICHAEL E. SYMONDS1,3, VIRGINIE SOTTILE1,4,*
BIOCELL, Vol.44, No.4, pp. 501-512, 2020, DOI:10.32604/biocell.2020.012942
Abstract Temperature is a key regulator of brown adipose tissue (BAT) function, acting through central sensory inputs to
influence metabolism and energy storage. Although animal models have produced a wealth of information on the
pathways, effectors and responses mediating the physiological response of adipose tissue to temperature in vivo, the
use of cell culture models now offers evidence of an additional cell-autonomous response to temperature changes, in
the absence of neural input. In particular, stem cell models provide new insight into the regulation of adipogenic
differentiation and the induction of browning features in vitro. Here the basis for adipogenic responsiveness to… More >
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