WENHAO XU^1,#, HAOMING LI^2,#, YASIR HAMEED³, MOSTAFA A. ABDEL-MAKSOUD⁴, SAEEDAH MUSAED ALMUTAIRI⁴, AYMAN MUBARAK⁴, MOHAMMED AUFY⁵, WAEL ALTURAIKI⁶, ABDULAZIZ J. ALSHALANI⁶, AYMAN M. MAHMOUD^7,*, CHEN LI^8,*

Oncology Research, Vol.31, No.5, pp. 819-831, 2023, DOI:10.32604/or.2023.029414 - 21 July 2023

Abstract N6-methyladenosine methylation (m6A) is a common type of epigenetic alteration that prominently affects the prognosis of tumor patients. However, it is unknown how the m6A regulator affects the tumor microenvironment (TME) cell infiltration in adrenocortical carcinoma (ACC) and how it affects the prognosis of ACC patients yet. The m6A alteration patterns of 112 ACC patients were evaluated, furthermore, the association with immune infiltration cell features was investigated. The unsupervised clustering method was applied to typify the m6A alteration patterns of ACC patients. The principal component analysis (PCA) technique was taken to create the m6A score… More >

Emma Sumner, Behram Cenk Acar, Matthew R. Acker

Canadian Journal of Urology, Vol.24, No.3, pp. 8865-8867, 2017

Abstract Oncocytic tumors arising from the adrenal gland are rare. Oncocytic adrenal neoplasms (OAN) may mimic adrenocortical carcinoma (ACC) at presentation, and can only be defnitively diagnosed histologically. Most OANs are benign, and carry a favorable prognosis. We report on an 83-year-old female who, while being investigated for anemia and weight loss, was found to have a 23 cm adrenal mass concerning for ACC. Adrenalectomy and histopathology confrmed a malignant OAN, based on theLin-Weiss-Biscegliacriteria.Wereportonthelargest non-functional, malignant OAN cited in the literature to date. OAN’s, though rare, can be considered in the differential diagnosis of large adrenal More >

Izak Faiena¹, Alexandra Tabakin¹, Jeffrey Leow², Neal Patel¹, Parth K. Modi¹, Amirali H. Salmasi¹, Benjamin I. Chung³, Steven L. Chang², Eric A. Singer¹

Canadian Journal of Urology, Vol.24, No.5, pp. 8990-8997, 2017

Abstract Introduction: Data on the utilization of open, laparoscopic and robotic adrenalectomy on a national level is limited.
Materials and methods: Data on patients who underwent open, laparoscopic, or robotic adrenalectomy for benign or malignant disease in the US from 2003-2013 were extracted using ICD-9 codes from the Premier Hospital Database. Surgeon specialty, patient demographics, hospital characteristics, and complications were compared. Data were analyzed using univariate and multivariable logistic regression analyses.
Results: A total of 8,831 adrenalectomies were performed for benign and malignant tumors. There was no significant difference in rate of adrenalectomy with regards to comorbidities, insurance status,… More >

Daniel J. Canter¹, Katherine Mallin², Robert G. Uzzo³, Brian L. Egleston³, Jay Simhan³, John Walton³, Marc C. Smaldone³, Viraj A. Master¹, Gennady Bratslavsky⁴, Alexander Kutikov³

Canadian Journal of Urology, Vol.20, No.5, pp. 6915-6921, 2013

Abstract Introduction: To assess the impact of size at presentation in patients with adrenocortical carcinoma (ACC) on rates of synchronous metastatic disease and survival following resection using a large administrative dataset.
Materials and methods: We queried the National Cancer Database (NCDB) dataset to assemble a cohort of patients with ACC based on SEER staging (1985-2000). Patients were stratified into three groups based on surgical tumor size cutoffs: < 4 cm, 4 cm-6 cm, and > 6 cm. Rates of metastatic disease at presentation in all ACC patients as well as relative survival for patients after resection of localized… More >

Jeffrey Gahan¹, Samir P. Shirodkar¹, Michael A. Gorin¹, Tomas A. Salerno², Gaetano Ciancio^1,3

Canadian Journal of Urology, Vol.18, No.3, pp. 5735-5738, 2011

Abstract Adrenocortical carcinoma with tumor thrombus and concomitant testosterone production is a rare entity. We describe a case of a 53-year-old woman with a testosterone producing left-sided adrenocortical carcinoma with tumor extending to the right atrium and tumor embolus to the right pulmonary artery. To our knowledge, there exist no such reported cases in the medical literature. We describe our use of techniques derived from transplant surgery for the removal of this mass. Critical components for successful resection included early renal artery ligation, hepatic mobilization off the inferior vena cava, and minimization of cardiopulmonary bypass time More >

Prashant Jani¹, Ahmed Lotfy Nasr², Dina El Demellawy¹

Canadian Journal of Urology, Vol.15, No.2, pp. 4016-4019, 2008

Abstract A case of synchronous adrenocortical carcinoma (ACC) and renal cell carcinoma (RCC) has not yet been described in the English medical literature, to our knowledge. We report a first such case of adrenocortical and renal cell carcinomas occurring simultaneously in a 53-year-old male. He presented with history of vague abdominal pain. Ultrasound followed by a computed tomography (CT) scan and a magnetic resonance imaging (MRI) examination revealed a 6.4 cm left adrenal mass and a 3.5 cm right renal mass. The patient had complaints of gastroparesis manifesting with constant nausea as well as intermittent abdominal More >

Karen M. Jones^1,2, Amar Singh³, Gabriel P. Haas³, Steve K. Landas¹

Canadian Journal of Urology, Vol.14, No.2, pp. 3518-3522, 2007

Abstract Adrenocortical carcinoma can have a clinical presentation that mimics a primary renal tumor. We describe a case of a 47-year-old male who presented with flank pain, weight loss, and a 14 cm mass arising from the upper pole of the right kidney on imaging. Upon surgical resection he was found to have a 1500 gram stage II adrenocortical carcinoma. The clinical features, pathologic findings, grading criteria, and differential diagnosis of adrenocortical carcinoma are reviewed. More >