WENHAO XU1,#, HAOMING LI2,#, YASIR HAMEED3, MOSTAFA A. ABDEL-MAKSOUD4, SAEEDAH MUSAED ALMUTAIRI4, AYMAN MUBARAK4, MOHAMMED AUFY5, WAEL ALTURAIKI6, ABDULAZIZ J. ALSHALANI6, AYMAN M. MAHMOUD7,*, CHEN LI8,*
Oncology Research, Vol.31, No.5, pp. 819-831, 2023, DOI:10.32604/or.2023.029414
Abstract N6-methyladenosine methylation (m6A) is a common type of epigenetic alteration that prominently affects the prognosis of tumor patients. However, it is unknown how the m6A regulator affects the tumor microenvironment (TME) cell infiltration in adrenocortical carcinoma (ACC) and how it affects the prognosis of ACC patients yet. The m6A alteration patterns of 112 ACC patients were evaluated, furthermore, the association with immune infiltration cell features was investigated. The unsupervised clustering method was applied to typify the m6A alteration patterns of ACC patients. The principal component analysis (PCA) technique was taken to create the m6A score to assess the alteration pattern… More >
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