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  • Open Access

    ARTICLE

    MASS TRANSFER MODELING OF HEPATIC DRUG ELIMINATION USING LOCAL VOLUME AVERAGING APPROACH

    Mohammad Izadifara,b,* , Jane Alcornc

    Frontiers in Heat and Mass Transfer, Vol.3, No.3, pp. 1-7, 2012, DOI:10.5098/hmt.v3.3.3005

    Abstract Applying local volume averaging method a mathematical model including liver porosity, tortuosity, permeability, unbound drug fraction, drugplasma diffusivity, axial/radial dispersion and hepatocellular metabolism parameters was developed for hepatic drug elimination. The model was numerically solved using implicit finite difference method to describe drug concentration gradient with time across the liver. Statistically validated by observations and other models, the model suggested axial dispersion as a significant variable in drug distribution across the liver. Sensitivity analyses revealed that lower liver porosity resulted in faster drug distribution across the liver, and bioavailability was sensitive to the interaction between unbound fraction and intrinsic clearance. More >

  • Open Access

    ARTICLE

    Transparent and Accurate COVID-19 Diagnosis: Integrating Explainable AI with Advanced Deep Learning in CT Imaging

    Mohammad Mehedi Hassan1,*, Salman A. AlQahtani2, Mabrook S. AlRakhami1, Ahmed Zohier Elhendi3

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.3, pp. 3101-3123, 2024, DOI:10.32604/cmes.2024.047940

    Abstract In the current landscape of the COVID-19 pandemic, the utilization of deep learning in medical imaging, especially in chest computed tomography (CT) scan analysis for virus detection, has become increasingly significant. Despite its potential, deep learning’s “black box” nature has been a major impediment to its broader acceptance in clinical environments, where transparency in decision-making is imperative. To bridge this gap, our research integrates Explainable AI (XAI) techniques, specifically the Local Interpretable Model-Agnostic Explanations (LIME) method, with advanced deep learning models. This integration forms a sophisticated and transparent framework for COVID-19 identification, enhancing the capability of standard Convolutional Neural Network… More >

  • Open Access

    ARTICLE

    Chitosan/Sodium Alginate Multilayer pH-Sensitive Films Based on Layer-by-Layer Self-Assembly for Intelligent Packaging

    Mingxuan He1, Yahui Zheng1, Jiaming Shen1, Jiawei Shi1, Yongzheng Zhang1, Yinghong Xiao2,*, Jianfei Che1,*

    Journal of Renewable Materials, Vol.12, No.2, pp. 215-233, 2024, DOI:10.32604/jrm.2023.043659

    Abstract

    The abuse of plastic food packaging has brought about severe white pollution issues around the world. Developing green and sustainable biomass packaging is an effective way to solve this problem. Hence, a chitosan/sodium alginate-based multilayer film is fabricated via a layer-by-layer (LBL) self-assembly method. With the help of superior interaction between the layers, the multilayer film possesses excellent mechanical properties (with a tensile strength of 50 MPa). Besides, the film displays outstanding water retention property (blocking moisture of 97.56%) and ultraviolet blocking property. Anthocyanin is introduced into the film to detect the food quality since it is one natural plant… More > Graphic Abstract

    Chitosan/Sodium Alginate Multilayer pH-Sensitive Films Based on Layer-by-Layer Self-Assembly for Intelligent Packaging

  • Open Access

    ARTICLE

    Robust and Trustworthy Data Sharing Framework Leveraging On-Chain and Off-Chain Collaboration

    Jinyang Yu1,2, Xiao Zhang1,2,3,*, Jinjiang Wang1,2, Yuchen Zhang1,2, Yulong Shi1,2, Linxuan Su1,2, Leijie Zeng1,2,*

    CMC-Computers, Materials & Continua, Vol.78, No.2, pp. 2159-2179, 2024, DOI:10.32604/cmc.2024.047340

    Abstract The proliferation of Internet of Things (IoT) systems has resulted in the generation of substantial data, presenting new challenges in reliable storage and trustworthy sharing. Conventional distributed storage systems are hindered by centralized management and lack traceability, while blockchain systems are limited by low capacity and high latency. To address these challenges, the present study investigates the reliable storage and trustworthy sharing of IoT data, and presents a novel system architecture that integrates on-chain and off-chain data manage systems. This architecture, integrating blockchain and distributed storage technologies, provides high-capacity, high-performance, traceable, and verifiable data storage and access. The on-chain system,… More >

  • Open Access

    ARTICLE

    Leveraging Augmented Reality, Semantic-Segmentation, and VANETs for Enhanced Driver’s Safety Assistance

    Sitara Afzal1, Imran Ullah Khan1, Irfan Mehmood2, Jong Weon Lee1,*

    CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 1443-1460, 2024, DOI:10.32604/cmc.2023.046707

    Abstract Overtaking is a crucial maneuver in road transportation that requires a clear view of the road ahead. However, limited visibility of ahead vehicles can often make it challenging for drivers to assess the safety of overtaking maneuvers, leading to accidents and fatalities. In this paper, we consider atrous convolution, a powerful tool for explicitly adjusting the field-of-view of a filter as well as controlling the resolution of feature responses generated by Deep Convolutional Neural Networks in the context of semantic image segmentation. This article explores the potential of seeing-through vehicles as a solution to enhance overtaking safety. See-through vehicles leverage… More >

  • Open Access

    ARTICLE

    A Deep Learning Approach for Landmines Detection Based on Airborne Magnetometry Imaging and Edge Computing

    Ahmed Barnawi1,*, Krishan Kumar2, Neeraj Kumar1, Bander Alzahrani1, Amal Almansour1

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 2117-2137, 2024, DOI:10.32604/cmes.2023.044184

    Abstract Landmines continue to pose an ongoing threat in various regions around the world, with countless buried landmines affecting numerous human lives. The detonation of these landmines results in thousands of casualties reported worldwide annually. Therefore, there is a pressing need to employ diverse landmine detection techniques for their removal. One effective approach for landmine detection is UAV (Unmanned Aerial Vehicle) based Airborne Magnetometry, which identifies magnetic anomalies in the local terrestrial magnetic field. It can generate a contour plot or heat map that visually represents the magnetic field strength. Despite the effectiveness of this approach, landmine removal remains a challenging… More >

  • Open Access

    REVIEW

    Congenital Absence of Pericardium: The Largest Systematic Review in the Field on 247 Worldwide Cases (1977-Now)

    Pier Paolo Bassareo1,2,3,*, Aurelio Secinaro4, Paolo Ciliberti5, Massimo Chessa6,7, Marco Alfonso Perrone5,8, Kevin Patrick Walsh1,2,3, Colin Joseph Mcmahon2,3

    Congenital Heart Disease, Vol.18, No.6, pp. 595-610, 2023, DOI:10.32604/chd.2023.046229

    Abstract Background: Congenital absence of pericardium (CAP), also known as pericardial agenesis, represents an uncommon cardiac abnormality and mostly incidental finding. It can be subdivided into complete and partial (left or right-sided) forms. Because of its infrequency, just case reports and a few case series have been released so far. This paper represents the largest systematic review in the field. Nine features (age at diagnosis, type, gender, clinical presentation, electrocardiography, imaging (ultrasounds, CT/MRI), concomitant cardiac defects, and outcome) were analysed. Methods: The electronic database PubMed was investigated from its establishment up to July 15th, 2023. Just case reports and case series… More >

  • Open Access

    ARTICLE

    A Novel Method for Aging Prediction of Railway Catenary Based on Improved Kalman Filter

    Jie Li1,3,*, Rongwen Wang2, Yongtao Hu1,3, Jinjun Li1

    Structural Durability & Health Monitoring, Vol.18, No.1, pp. 73-90, 2024, DOI:10.32604/sdhm.2023.044023

    Abstract The aging prediction of railway catenary is of profound significance for ensuring the regular operation of electrified trains. However, in real-world scenarios, accurate predictions are challenging due to various interferences. This paper addresses this challenge by proposing a novel method for predicting the aging of railway catenary based on an improved Kalman filter (KF). The proposed method focuses on modifying the priori state estimate covariance and measurement error covariance of the KF to enhance accuracy in complex environments. By comparing the optimal displacement value with the theoretically calculated value based on the thermal expansion effect of metals, it becomes possible… More > Graphic Abstract

    A Novel Method for Aging Prediction of Railway Catenary Based on Improved Kalman Filter

  • Open Access

    ARTICLE

    Leveraging diverse cell-death patterns to predict the clinical outcome of immune checkpoint therapy in lung adenocarcinoma: Based on muti-omics analysis and vitro assay

    HONGYUAN LIANG1,#, YANQIU LI2,#, YONGGANG QU3, LINGYUN ZHANG4,*

    Oncology Research, Vol.32, No.2, pp. 393-407, 2024, DOI:10.32604/or.2023.031134

    Abstract Advanced LUAD shows limited response to treatment including immune therapy. With the development of sequencing omics, it is urgent to combine high-throughput multi-omics data to identify new immune checkpoint therapeutic response markers. Using GSE72094 (n = 386) and GSE31210 (n = 226) gene expression profile data in the GEO database, we identified genes associated with lung adenocarcinoma (LUAD) death using tools such as “edgeR” and “maftools” and visualized the characteristics of these genes using the “circlize” R package. We constructed a prognostic model based on death-related genes and optimized the model using LASSO-Cox regression methods. By calculating the cell death… More >

  • Open Access

    ARTICLE

    From Social Media to Ballot Box: Leveraging Location-Aware Sentiment Analysis for Election Predictions

    Asif Khan1, Nada Boudjellal2, Huaping Zhang1,*, Arshad Ahmad3, Maqbool Khan3

    CMC-Computers, Materials & Continua, Vol.77, No.3, pp. 3037-3055, 2023, DOI:10.32604/cmc.2023.044403

    Abstract Predicting election outcomes is a crucial undertaking, and various methods are employed for this purpose, such as traditional opinion polling, and social media analysis. However, traditional polling approaches often struggle to capture the intricate nuances of voter sentiment at local levels, resulting in a limited depth of analysis and understanding. In light of this challenge, this study focuses on predicting elections at the state/regional level along with the country level, intending to offer a comprehensive analysis and deeper insights into the electoral process. To achieve this, the study introduces the Location-Based Election Prediction Model (LEPM), which utilizes social media data,… More >

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