Weiguang Yang1, Frank L. Hanley2, Frandics P. Chan3, Alison L. Marsden1,4, Irene E. Vignon-Clementel5, Jeffrey A. Feinstein1,4
Congenital Heart Disease, Vol.13, No.2, pp. 241-250, 2018, DOI:10.1111/chd.12556
Abstract Background: Up to 90% of individuals with Alagille syndrome have congenital heart diseases.
Peripheral pulmonary artery stenosis (PPS), resulting in right ventricular hypertension and pulmonary flow disparity, is one of the most common abnormalities, yet the hemodynamic effects are illdefined, and optimal patient management and treatment strategies are not well established. The
purpose of this pilot study is to use recently refined computational simulation in the setting of multiple surgical strategies, to examine the influence of pulmonary artery reconstruction on
hemodynamics in this population.
Materials and Methods: Based on computed tomography angiography and cardiac catheterization
data, preoperative pulmonary artery models… More >
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