LUCIANA MAZZEI1,2, MARÍA BELÉN RUIZ-ROSO3, NATALIA DE LAS HERAS3, SANDRA BALLESTEROS3, CAROLINA TORRESPALAZZOLO4, LEÓN FERDER5, ALEJANDRA BEATRIZ CAMARGO4, WALTER MANUCHA1,2,*
BIOCELL, Vol.44, No.4, pp. 671-681, 2020, DOI:10.32604/biocell.2020.014175
Abstract The ancestral cultures have described many therapeutic properties of garlic; therefore, it is of central interest to
elucidate the molecular basis explaining this millenary empirical knowledge. Indeed, it has been demonstrated a
neuroprotective effect of allicin–a phytochemical present in garlic- linked to oxidative-inflammatory modulation.
Allicin improved neuronal injury by heat shock protein 70 (Hsp70) and inducible nitric oxide synthase (iNOS)
regulation. Also, allicin exerts renal protection involving a possible angiotensin type 1 receptor (AT1) interaction. In
connection, AT1 overexpression has been recognized as a central deleterious factor in many brain diseases. However,
there are no studies that evaluate AT1-Hsp70-iNOS interaction… More >
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