SHAOFENG XIONG^1,2, WENKAI LV³, GUOSHENG CAO⁴, LONGSHENG FU¹, WEN LIU³, MENGFAN LEI², YANNI LV^1,5,*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.073401 - 23 January 2026

Abstract Objective: Leucine-rich alpha-2 glycoprotein 1 (Lrg1) could regulate diverse cells in cerebral ischemia-reperfusion. Our study seeks to uncover Lrg1’s impact on endothelial cell heterogeneity via differentiation pathways and transcription factors. Method: The CSOmap model measured cell-to-brain-center distances using single-cell RNA sequencing (scRNA-seq) data in middle cerebral artery occlusion reperfusion (MCAO/R). Monocle2 mapped endothelial differentiation paths. Gene set enrichment analysis (GSEA) analyzed endothelial subcluster variations. Database searches revealed a zinc finger MIZ-type containing 1 protein-frizzled 3 (Zmiz1-Fzd3) promoter interaction. Endothelial cells were transfected with a Fzd3 promoter-luciferase plasmid. Polymerase chain reaction (PCR) and western blotting assessed… More >

Williams Kyei^*, Chunyong Yin, Kelvin Amos Nicodemas, Khagendra Darlami

Journal on Artificial Intelligence, Vol.8, pp. 19-38, 2026, DOI:10.32604/jai.2026.074988 - 20 January 2026

Abstract The COVID-19 pandemic has underscored the need for rapid and accurate diagnostic tools to differentiate respiratory infections from normal cases using chest X-rays (CXRs). Manual interpretation of CXRs is time-consuming and prone to errors, particularly in distinguishing COVID-19 from viral pneumonia. This research addresses these challenges by proposing a customized EfficientNet-B0 model for ternary classification (COVID-19, Viral Pneumonia, Normal) on the COVID-19 Radiography Database. Employing transfer learning with architectural modifications, including a tailored classification head and regularization techniques, the model achieves superior performance. Evaluated via accuracy, F1-score (macro-averaged), AUROC (macro-averaged), precision (macro-averaged), recall (macro-averaged), inference… More >

Marco Siringo^1,2,#,*, Michela De Meo^1,#, Alain Jonathan Gelibter³, Chiara Nicolazzo^4,5,§, Paola Gazzaniga^5,§

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.069832 - 19 January 2026

Abstract Objectives: Although immune checkpoint inhibitors (ICIs) and targeted therapies have reshaped treatment non-small cell lung cancer (NSCLC) paradigms, prognosis remains poor for many patients due to delayed diagnosis and resistance mechanisms. Liquid biopsy offers a minimally invasive approach to monitoring tumor evolution. Among circulating biomarkers, circulating tumor cells (CTCs) and cancer-associated macrophage-like cells (CAM-Ls) may provide complementary prognostic insights. The study aimed to evaluate the prognostic role of CTC and CAM-Ls dynamic in metastatic NSCLC patients. Methods: We retrospectively analyzed 77 patients with metastatic NSCLC who underwent CTC and CAM-L evaluation via the CellSearch® system… More >

José Armando Santas Ciavatta, Juan Ramón Bermejo Higuera^*, Javier Bermejo Higuera, Juan Antonio Sicilia Montalvo, Tomás Sureda Riera, Jesús Pérez Melero

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.074566 - 12 January 2026

Abstract As artificial Intelligence (AI) continues to expand exponentially, particularly with the emergence of generative pre-trained transformers (GPT) based on a transformer’s architecture, which has revolutionized data processing and enabled significant improvements in various applications. This document seeks to investigate the security vulnerabilities detection in the source code using a range of large language models (LLM). Our primary objective is to evaluate the effectiveness of Static Application Security Testing (SAST) by applying various techniques such as prompt persona, structure outputs and zero-shot. To the selection of the LLMs (CodeLlama 7B, DeepSeek coder 7B, Gemini 1.5 Flash,… More >

Danping Niu¹, Yuan Ping^1,*, Chun Guo², Xiaojun Wang³, Bin Hao⁴

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.073630 - 12 January 2026

Abstract With the increasing complexity of malware attack techniques, traditional detection methods face significant challenges, such as privacy preservation, data heterogeneity, and lacking category information. To address these issues, we propose Federated Dynamic Prototype Learning (FedDPL) for malware classification by integrating Federated Learning with a specifically designed K-means. Under the Federated Learning framework, model training occurs locally without data sharing, effectively protecting user data privacy and preventing the leakage of sensitive information. Furthermore, to tackle the challenges of data heterogeneity and the lack of category information, FedDPL introduces a dynamic prototype learning mechanism, which adaptively adjusts the More >

Nikita Golovkin^1,2, Olesya Nikulenkova³, Vsevolod Pobezhimov¹, Alexander Nesmelov¹, Sergei Chvalun¹, Fedor Sorokin³, Arthur Krupnin^1,3,*

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.073161 - 12 January 2026

Abstract This study presents and verifies a hybrid methodology for reliable determination of parameters in structural rheological models (Zener, Burgers, and Maxwell) describing the viscoelastic behavior of polyurethane specimens manufactured using extrusion-based 3D printing. Through comprehensive testing, including cyclic compression at strain rates ranging from 0.12 to 120 mm/min (0%–15% strain) and creep/relaxation experiments (10%–30% strain), the lumped parameters were independently determined using both analytical and numerical solutions of the models’ differential equations, followed by cross-verification in additional experiments. Numerical solutions for creep and relaxation problems were obtained using finite element analysis, with the three-parameter Mooney-Rivlin… More > Graphic Abstract

Rayeesa Mehmood^*, Sergei Koltcov, Anton Surkov, Vera Ignatenko

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.072735 - 12 January 2026

Abstract Activation pruning reduces neural network complexity by eliminating low-importance neuron activations, yet identifying the critical pruning threshold—beyond which accuracy rapidly deteriorates—remains computationally expensive and typically requires exhaustive search. We introduce a thermodynamics-inspired framework that treats activation distributions as energy-filtered physical systems and employs the free energy of activations as a principled evaluation metric. Phase-transition–like phenomena in the free-energy profile—such as extrema, inflection points, and curvature changes—yield reliable estimates of the critical pruning threshold, providing a theoretically grounded means of predicting sharp accuracy degradation. To further enhance efficiency, we propose a renormalized free energy technique that More >

José Arturo Ramírez-Fernández¹, Henevith G. Méndez-Figueroa¹, Sebastián Ossandón^2,*, Ricardo Galván-Martínez³, Miguel Ángel Hernández-Pérez³, Ricardo Orozco-Cruz³

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.072707 - 12 January 2026

Abstract In this study, artificial neural networks (ANNs) were implemented to determine design parameters for an impressed current cathodic protection (ICCP) prototype. An ASTM A36 steel plate was tested in 3.5% NaCl solution, seawater, and NS4 using electrochemical impedance spectroscopy (EIS) to monitor the evolution of the substrate surface, which affects the current required to reach the protection potential (Eprot). Experimental data were collected as training datasets and analyzed using statistical methods, including box plots and correlation matrices. Subsequently, ANNs were applied to predict the current demand at different exposure times, enabling the estimation of electrochemical More >

Mohammed Alnusayri¹, Ghulam Mujtaba², Nouf Abdullah Almujally³, Shuoa S. Aitarbi⁴, Asaad Algarni⁵, Ahmad Jalal^2,6, Jeongmin Park^7,*

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.071804 - 12 January 2026

Abstract This paper presents a unified Unmanned Aerial Vehicle-based (UAV-based) traffic monitoring framework that integrates vehicle detection, tracking, counting, motion prediction, and classification in a modular and co-optimized pipeline. Unlike prior works that address these tasks in isolation, our approach combines You Only Look Once (YOLO) v10 detection, ByteTrack tracking, optical-flow density estimation, Long Short-Term Memory-based (LSTM-based) trajectory forecasting, and hybrid Speeded-Up Robust Feature (SURF) + Gray-Level Co-occurrence Matrix (GLCM) feature engineering with VGG16 classification. Upon the validation across datasets (UAVDT and UAVID) our framework achieved a detection accuracy of 94.2%, and 92.3% detection accuracy when More >

Jinfeng Ji¹, Geunseok Yang^2,*

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.071733 - 12 January 2026

Abstract Automated Program Repair (APR) techniques have shown significant potential in mitigating the cost and complexity associated with debugging by automatically generating corrective patches for software defects. Despite considerable progress in APR methodologies, existing approaches frequently lack contextual awareness of runtime behaviors and structural intricacies inherent in buggy source code. In this paper, we propose a novel APR approach that integrates attention mechanisms within an autoencoder-based framework, explicitly utilizing structural code affinity and execution context correlation derived from stack trace analysis. Our approach begins with an innovative preprocessing pipeline, where code segments and stack traces are… More >