Fengyun Hao*1, Qingli Zhu†, Lingwei Lu†, Shukai Sun‡, Yichuan Huang§, Jinna Zhang¶,
Zhaohui Liu†#, Yuanqing Miao**, Xuelong Jiao††, Dong Chen††1
Oncology Research, Vol.28, No.4, pp. 345-355, 2020, DOI:10.3727/096504020X15834065061807
Abstract Anaplastic thyroid carcinoma (ATC) is resistant to standard therapies and has no effective treatment. Eukaryotic
translation initiation factor 5A2 (EIF5A2) has shown to be upregulated in many malignant tumors and proposed to be a critical gene involved in tumor metastasis. In this study, we aimed to investigate the expression
status of EIF5A2 in human ATC tissues and to study the role and mechanisms of EIF5A2 in ATC tumorigenesis
in vitro and in vivo. Expression of EIF5A2 protein was analyzed in paraffin-embedded human ATC tissues
and adjacent nontumorous tissues (ANCT) (n = 24) by immunochemistry. Expressions of EIF5A2 mRNA and
protein… More >
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