Yidan Chen#,1, Kang Zhang#,1, Juhui Qiu1, Shicheng He1, Junyang Huang2, Lu Huang1, Dongyu Jia3, Bo Ling1, Da Sun4, Xiang Xie1, Tieying Yin*,1, Guixue Wang*,1
Molecular & Cellular Biomechanics, Vol.14, No.2, pp. 83-100, 2017, DOI:10.3970/mcb.2017.014.081
Abstract Abnormal shear stress in the blood vessel is an important stimulating factor for the formation of angiogenesis and vulnerable plaques. This paper intended to explore the role of shear stress-regulated Id1 in angiogenesis. First, we applied a carotid artery ring ligation to create local stenosis in ApoE-/- mice. Then, 3D geometry of the vessel network was reconstructed based on MRI, and our analysis of computational fluid dynamics revealed that wall shear stress of the proximal region was much higher than that of the distal region. In addition, results from histological staining of the proximal region found more vulnerable-probe plaques with… More >
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