ZEPENG DONG, CHENYE ZHAO, SHIBO HU, KUI YANG, JUNHUI YU*, XUEJUN SUN, JIANBAO ZHENG*
BIOCELL, Vol.47, No.12, pp. 2735-2745, 2023, DOI:10.32604/biocell.2023.043422
Abstract Objectives: Angiogenesis plays a significant role in the occurrence and development of inflammatory bowel disease (IBD). The aim of this study is to explore potential angiogenesis related genes (ARGs) in IBD through bioinformatics analysis and in vivo experiments. Methods: GSE57945, GSE87466, and GSE36807 were obtained from the Gene Expression Omnibus database. GSE57945 was used as the training set, while GSE87466 and GSE36807 were used as the validation set. The key ARGs associated with IBD were identified using the least absolute shrinkage and selection operator (LASSO) and random forest methods. These identified ARGs were then utilized to construct a diagnostic model… More >
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