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    3D Numerical Simulation of Effect of Antiangiogenic Factor Angiostatin on Blood Flow and Interstitial Fluid Pressure in the Metastatic Tumor

    Gaiping Zhao1, Feiyi Xia1, Eryun Chen2, Xiaoli Yu3, Zhaozhi Yang3,*

    Molecular & Cellular Biomechanics, Vol.14, No.1, pp. 47-57, 2017, DOI:10.3970/mcb.2017.014.049

    Abstract Metastatic tumor blood perfusion and interstitial fluid transport based on 3D microvasculature response to inhibitory effect of angiostatin are investigated in this paper. 3D blood flow、interstitial fluid transport and transvascular flow are described by the extended Poiseuille’s, Darcy’s and Starling’s law, respectively. Numerical solutions reveal that angiostatin can promote improved blood perfusion and decrease elevated interstitial fluid pressure within the metastatic tumor microenvironment. Moreover, angiostatin can increase interstitial convection within the tumor and result in more efficient drug delivery and penetration within the metastatic tumor, which suits well with the experimental observations. Together, our results may provide therapeutic implications for… More >

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