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    Vitamin D3 attenuates anxiety-like behavior in long-term ovariectomized rats with unpredictable mild stress

    Denis BARANENKO1, Julia FEDOTOVA1, 2, *, Annemieke Johanna Maria VAN DEN TOL3

    BIOCELL, Vol.43, No.4, pp. 299-311, 2019, DOI:10.32604/biocell.2019.08407

    Abstract The impact of various vitamin D3 (VD3) doses (1.0, 2.5, or 5 mg/kg, s.c.) in mitigating the negative consequences of chronic unpredictable mild stress (CUMS) was investigated. Adult female rats with long-term estrogen deficiency were assessed using the sucrose preference test (SPT), the elevated plus-maze (EPM), the light/dark test (LDT), and the open-field test (OFT) to measure anhedonia-like and anxiety-like behavior. The corticosterone (CS) and adrenocorticotrophic hormone (ACTH) concentrations in blood serum and the brain-derived neurotrophic factor (BDNF) expression in the hippocampus of long-term ovariectomized (OVX) rats were measured by ELISA kits and/ or western… More >

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