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  • Open Access


    Exercise Catheterization for Hemodynamic Evaluation of Adults with Coarctation of the Aorta

    Irene Martin de Miguel1, C. Charles Jain1, Alexander C. Egbe1, Jason H. Anderson2, Heidi M. Connolly1, William R. Miranda1,*

    Congenital Heart Disease, Vol.17, No.6, pp. 605-615, 2022, DOI:10.32604/chd.2022.023969

    Abstract Background: Coarctation of the aorta (CoA) is associated with a generalized arteriopathy and long-term complications despite repair. Data on invasive exercise hemodynamics in this population are lacking. Accordingly, we reviewed adults with CoA undergoing exercise catheterization to assess 1. hemodynamic profile; 2. feasibility for assessment of CoA severity. Methods: Twenty patients undergoing exercise cardiac catheterization (12 arm adduction and 8 supine cycle ergometry) at a quaternary care center between 2004 and 2021 were identified. Resting and exercise hemodynamic data were abstracted from the procedure logs. Results: Mean age was 43.6 ± 12.0 years. Eleven patients (55%) had resting pulmonary arterial wedge pressure… More >

  • Open Access


    Predictors and Effects of Persistent Hypertension after Successful Treatment of Coarctation of the Aorta

    Mohamed Saber Hafez*, Alaa Roushdy, Dina Ezzeldin

    Congenital Heart Disease, Vol.17, No.3, pp. 325-333, 2022, DOI:10.32604/chd.2022.019025

    Abstract Background: Coarctation of the aorta is a congenital heart disease that sometimes remains clinically silent until adulthood, usually presenting with arterial hypertension. It is well known that after coarctation treatment, many patients remain hypertensive despite successful repair. In this study we approached the predictors and effects of residual hypertension after successful coarctation therapy. Methods: It was a cross sectional observational study involving 50 patients who underwent Coarctation repair/angioplasty in Ain Shams university hospitals. We divided the patients into two groups (hypertensive and normotensive) and we studied their demographic data (e.g., age, gender, age at first repair, follow up period, etc.)… More >

  • Open Access


    Computation of Aortic Geometry Using MR and CT 3D Images

    Maryam Altalhi1, Sami Ur Rehman2, Fakhre Alam2, Ala Abdulsalam Alarood3, Amin ur Rehman2, M. Irfan Uddin4,*

    Intelligent Automation & Soft Computing, Vol.31, No.2, pp. 961-969, 2022, DOI:10.32604/iasc.2022.020607

    Abstract The proper computation of geometric parameters of the aorta and coronary arteries are very important for surgery planning, disease diagnoses, and age-related changes observation in the vessels. The accurate knowledge about the geometry of aorta and coronary arteries is required for the proper investigation of heart related diseases. The geometry of aorta and coronary arteries includes the diameter of the ascending and descending aorta and coronary arteries, length of the coronary arteries, branching angles of the coronary arteries and branching points. These geometric parameters from arteries can be computed from the 3D image data. In this paper, we propose an… More >

  • Open Access


    When the Blood Pressure Misleads You: A Diagnostic Conundrum in an Unusual Case of Coarctation

    Eva Kapravelou1, Hugo Issa2, Gordon Culham3, Martin Hosking1, Sanjiv K. Gandhi2, Shubhayan Sanatani1,*

    Congenital Heart Disease, Vol.16, No.6, pp. 675-680, 2021, DOI:10.32604/CHD.2021.016548

    Abstract A 4-month-old previously healthy baby was found to be in congestive heart failure with LV dysfunction and a right aortic arch with severe coarctation, undetectable by blood pressure measurements. A cardiac CT and central blood pressure led to the diagnosis of a unique anatomic variant of aortic coarctation. Once diagnosed the patient underwent surgery with an uncomplicated recovery. More >

  • Open Access


    Haemodynamic Analysis of the Relationship between the Morphological Alterations of the Ascending Aorta and the Type A Aortic-Dissection Disease

    Qingzhuo Chi1, Huimin Chen1, Lizhong Mu1,*, Ying He1, Yong Luan2

    FDMP-Fluid Dynamics & Materials Processing, Vol.17, No.4, pp. 721-743, 2021, DOI:10.32604/fdmp.2021.015200

    Abstract Type A aortic dissection (AD) is one of the most serious cardiovascular diseases, whose risk predictors are controversial. The purpose of this research was to investigate how elongation accompanied by dilation of the ascending aorta (AAo) affects the relevant haemodynamic characteristics using image-based computational models. Five elongated AAos with different levels of dilation have been reconstructed based on the centerlines data of an elderly and an AD patient. Numerical simulations have been performed assuming an inflow waveform and a Windkessel model with three elements for all outflow boundaries. The numerical results have revealed that the elongation of AAo can disturb… More >

  • Open Access


    Efficacy and Safety of the Atrial Septal Defect Closure for Patients with Absent or Malaligned Aortic Rim Using a Figulla Flex II Device Flared and Straddling Behind the Aorta

    Masataka Kitano1,2,*, Kazuto Fujimoto1, Atsuko Kato1, Ken-ichi Kurosaki1, Isao Shiraishi1

    Congenital Heart Disease, Vol.16, No.3, pp. 269-283, 2021, DOI:10.32604/CHD.2021.015308

    Abstract Background: Although transcatheter closure of atrial septal defect (ASD) is safe and effective for patients with sufficient rim, ASD patients with absent and/or malaligned aortic and/or superior rim have higher risks of device embolization and cardiac erosion. We have treated such high-risk patients using a Figulla Flex II (FFII) device shaped flared and straddling behind the aorta because this method would avoid such serious complications. However, its long-term efficacy and safety remain unclear. Therefore, the midterm efficacy and safety of this method were studied. Methods: We retrospectively evaluated the outcome of 47 consecutive patients with such rim (age 6–73 years,… More >

  • Open Access


    Effect of Patient-Specific Aorta Wall Properties on Hemodynamic Parameters

    Mohamad Shukri Zakaria1,*, Haslina Abdullah2, Azmi Nordin1, Syazwati Ahmad Zaki1

    FDMP-Fluid Dynamics & Materials Processing, Vol.17, No.1, pp. 171-179, 2021, DOI:10.32604/fdmp.2021.010974

    Abstract This study deals with the interaction of blood flow with the wall aorta, i.e., the boundary of the main artery that transports blood in the human body. The problem is addressed in the framework of computational fluid dynamics complemented with (FSI), i.e., a fluid-structure interaction model. Two fundamental types of wall are considered, namely a flexible and a rigid boundary. The resulting hemodynamic flows are carefully compared in order to determine which boundary condition is more effective in reproducing reality. Special attention is paid to wall shear stress (WSS), a factor known for its ability to produce atherosclerosis and bulges.… More >

  • Open Access


    Screening Coarctation of Aorta with Clinical and Echocardiographic Profiles in Infants: A Pilot Study

    Ruikun Zou1, Yifei Wang1,*, Chengcheng Pang2, Yunxia Sun1, Chen Chen1, Jian Zhuang3

    Congenital Heart Disease, Vol.16, No.2, pp. 159-170, 2021, DOI:10.32604/CHD.2021.015050

    Abstract Aim: To determine the profiles of clinical features including four-limb blood pressure (BP), saturations of peripheral oxygen (SpO2), and echocardiographic features in infants with coarctation of aorta (CoA) to facilitate congenital heart diseases screening. Methods: The charts of infants with CoA were retrospectively reviewed. All in-hospital infants suspected of congenital heart diseases by clinical teams were prospectively measured of four limbs BPs and SpO2 in a regional cardiac transferring center during 2013 and 2019. Echocardiography as a gold standard test was followed within 2 days after suspicion. All infants were divided into non-significant CoA group or significant CoA group based… More >

  • Open Access


    Numerical Simulation of Blood Flow in Aorta with Dilation: A Comparison between Laminar and LES Modeling Methods

    Lijian Xu1, Tianyang Yang2, Lekang Yin3, Ye Kong2, Yuri Vassilevski4,5, Fuyou Liang1,5,6,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.124, No.2, pp. 509-526, 2020, DOI:10.32604/cmes.2020.010719

    Abstract Computational modeling methods have been increasingly employed to quantify aortic hemodynamic parameters that are challenging to in vivo measurements but important for the diagnosis/treatment of aortic disease. Although the presence of turbulence-like behaviors of blood flow in normal or diseased aorta has long been confirmed, the majority of existing computational model studies adopted the laminar flow assumption (LFA) in the treatment of sub-grid flow variables. So far, it remains unclear whether LFA would significantly compromise the reliability of hemodynamic simulation. In the present study, we addressed the issue in the context of a specific aortopathy, namely aortic dilation, which is… More >

  • Open Access


    Cardiovascular risk factors in adults with coarctation of the aorta

    Maria Fedchenko, Zacharias Mandalenakis, Helena Dellborg, Görel Hultsberg‐Olsson, Anna Björk, Peter Eriksson, Mikael Dellborg

    Congenital Heart Disease, Vol.14, No.4, pp. 549-558, 2019, DOI:10.1111/chd.12785

    Abstract Background: The aging patient with adult congenital heart disease (ACHD) faces the risk of developing atherosclerotic disease. Patients with coarctation of the aorta (CoA) are especially vulnerable because of an inherent high risk of developing hy‐ pertension. However, data on the prevalence of other cardiovascular risk factors are scarce. Therefore, this study aimed to describe the prevalence of traditional cardio‐ vascular risk factors (diabetes, hypertension, hyperlipidemia, smoking, obesity, and sedentary lifestyle) in adult patients with CoA.
    Methods: Patients with CoA who were registered at the ACHD clinic in Gothenburg were asked to participate in a comprehensive cardiovascular risk assessment. This… More >

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