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  • Open Access


    Bicuspidization Using the Open-Sleeve Technique for Congenital Aortic Stenosis during Infancy

    Toshi Maeda*, Hiroki Ito, Keiichi Hirose, Kisaburo Sakamoto

    Congenital Heart Disease, Vol.19, No.2, pp. 177-183, 2024, DOI:10.32604/chd.2024.050945

    Abstract Congenital aortic stenosis (cAS) frequently requires intervention during the neonatal or infantile period. However, surgical repair is challenging because of the narrow surgical space. We performed bicuspidization using the open-sleeve technique for cAS with a unicuspid aortic valve in two patients. Postoperatively, the patients were doing well without reintervention for the aortic valve for 8 and 6 years, respectively. Their aortic annular diameter increased along with somatic growth. Bicuspidization for neonates or infancy can be performed safely using the open-sleeve technique as its midterm results have been satisfactory. More > Graphic Abstract

    Bicuspidization Using the Open-Sleeve Technique for Congenital Aortic Stenosis during Infancy

  • Open Access


    Machine Learning Prediction Models of Optimal Time for Aortic Valve Replacement in Asymptomatic Patients

    Salah Alzghoul1,*, Othman Smadi1, Ali Al Bataineh2, Mamon Hatmal3, Ahmad Alamm4

    Intelligent Automation & Soft Computing, Vol.37, No.1, pp. 455-470, 2023, DOI:10.32604/iasc.2023.038338

    Abstract Currently, the decision of aortic valve replacement surgery time for asymptomatic patients with moderate-to-severe aortic stenosis (AS) is made by healthcare professionals based on the patient’s clinical biometric records. A delay in surgical aortic valve replacement (SAVR) can potentially affect patients’ quality of life. By using ML algorithms, this study aims to predict the optimal SAVR timing and determine the enhancement in moderate-to-severe AS patient survival following surgery. This study represents a novel approach that has the potential to improve decision-making and, ultimately, improve patient outcomes. We analyze data from 176 patients with moderate-to-severe aortic… More >

  • Open Access


    Combined Surgical Treatment of Atherosclerotic Coronary Artery Disease and Moderate Aortic Valve Stenosis in Patient with Concomitant Lipton’s R-III Type of Single Coronary Artery Anomaly

    Milica Karadzic Kocica1, Hristina Ugrinovic1, Dejan Lazovic2, Nemanja Karamarkovic2, Milos Grujic2, Borivoje Lukic3, Oliver Radmili3, Vladimir Cvetic3, Mladen Kocica2,*

    Congenital Heart Disease, Vol.16, No.6, pp. 647-653, 2021, DOI:10.32604/CHD.2021.016923

    Abstract A single coronary artery is a very rare condition, commonly associated with other congenital anomalies. It could be generally considered as neither benign nor malignant form of congenital coronary artery anomalies since its pathophysiological and clinical implications grossly depend on different anatomical patterns defined by the site of origin and distribution of the branches. By presenting the patient who underwent successful coronary artery bypass grafting and aortic valve replacement surgery in a presence of isolated single coronary artery, we intend to emphasize natural and procedural risks and distinguish casual from causal in this extremely rare More >

  • Open Access


    Fluid-Structure Interaction in Problems of Patient Specific Transcatheter Aortic Valve Implantation with and Without Paravalvular Leakage Complication

    Adi Azriff Basri1,6,*, Mohammad Zuber2, Ernnie Illyani Basri1, Muhammad Shukri Zakaria5, Ahmad Fazli Abd Aziz3, Masaaki Tamagawa4, Kamarul Arifin Ahmad1,6

    FDMP-Fluid Dynamics & Materials Processing, Vol.17, No.3, pp. 531-553, 2021, DOI:10.32604/fdmp.2021.010925

    Abstract Paravalvular Leakage (PVL) has been recognized as one of the most dangerous complications in relation to Transcathether Aortic Valve Implantation (TAVI) activities. However, data available in the literature about Fluid Structure Interaction (FSI) for this specific problem are relatively limited. In the present study, the fluid and structure responses of the hemodynamics along the patient aorta model and the aortic wall deformation are studied with the aid of numerical simulation taking into account PVL and 100% TAVI valve opening. In particular, the aorta without valve (AWoV) is assumed as the normal condition, whereas an aorta… More >

  • Open Access


    The Prognostic Value of Myocardial Deformation in Patients with Congenital Aortic Stenosis

    Roderick W. J. van Grootel, Allard T. van den Hoven, Dan Bowen, Tijmen Ris, Jolien W. Roos-Hesselink, Annemien E. van den Bosch*

    Congenital Heart Disease, Vol.16, No.3, pp. 221-232, 2021, DOI:10.32604/CHD.2021.013793

    Abstract Aims: To assess the prognostic value of left ventricular (LV) global longitudinal strain (GLS) and global longitudinal early diastolic strain rate (GLSre) with regard to cardiovascular events, as congenital aortic stenosis (AoS) is associated with significant mortality and morbidity but predictors for clinical outcome are scarce. Strain analysis provides a robust and reproducible method for early detection of LV dysfunction, which might be of prognostic value. Methods: This prospective study, included clinically stable patients with congenital AoS between 2011–2013. LV GLS and GLSre was performed in the apical 4, 3 and 2-chamber views using Tomtec software.… More >

  • Open Access


    Temporal relationship between instantaneous pressure gradients and peak-to-peak systolic ejection gradient in congenital aortic stenosis

    Brian A. Boe1, Mark D. Norris2, Jeffrey D. Zampi2, Albert P. Rocchini2, Gregory J. Ensing2

    Congenital Heart Disease, Vol.12, No.6, pp. 733-739, 2017, DOI:10.1111/chd.12514

    Abstract Objective: We sought to identify a time during cardiac ejection when the instantaneous pressure gradient (IPG) correlated best, and near unity, with peak-to-peak systolic ejection gradient (PPSG) in patients with congenital aortic stenosis. Noninvasive echocardiographic measurement of IPG has limited correlation with cardiac catheterization measured PPSG across the spectrum of disease severity of congenital aortic stenosis. A major contributor is the observation that these measures are inherently different with a variable relationship dependent on the degree of stenosis.
    Design: Hemodynamic data from cardiac catheterizations utilizing simultaneous pressure measurements from the left ventricle (LV) and ascending aorta (AAo)… More >

  • Open Access


    Long‐term cardiovascular outcome of Williams syndrome

    Seul Gi Cha1, Mi Kyung Song1, Sang Yun Lee1, Gi Beom Kim1, Jae Gun Kwak2, Woong Han Kim2, Eun Jung Bae1

    Congenital Heart Disease, Vol.14, No.5, pp. 684-690, 2019, DOI:10.1111/chd.12810

    Abstract Objective: Cardiovascular lesions are the leading cause of morbidity and mortality in patients with Williams syndrome. Recent studies have rebutted conventional reports about the natural course of cardiovascular anomalies in Williams syndrome.
    Design: Retrospective study.
    Setting: Single tertiary center.
    Patients: Eighty patients with Williams syndrome followed up for more than 5 years.
    Interventions: Not applicable.
    Outcome Measures: Long‐term outcome of cardiovascular lesions, peak velocity change in obstructive cardiovascular lesions over time, post‐interventional courses of disease‐specific intervention, and intervention‐free survival of obstructive cardio‐ vascular lesions.
    Results: The median follow‐up duration was 11.0 (5.1‐28.3) years. Among 80 pa‐ tients, supravalvular aortic stenosis (87.5%) was… More >

  • Open Access


    Bicuspid and Unicuspid Aortic Valve: Fate of Moderate/Severe Mixed Aortic Valve Disease

    Alexander C. Egbe*, Heidi M. Connolly*, Joseph T. Poterucha*,†, Carole A. Warnes*

    Congenital Heart Disease, Vol.12, No.1, pp. 24-31, 2017

    Abstract Objectives. There is a paucity of data about mixed aortic valve disease (MAVD) in patients with bicuspid/unicuspid aortic valve (BAV). This study sought to describe the outcomes of patients with moderate/severe MAVD.
    Methods. We queried our database for patients with BAV and moderate/severe MAVD seen between 1994 and 2013. We excluded patients with baseline New York Heart Association (NYHA) III/IV symptoms, left ventricular ejection fraction <50%, aortic dimension >50 mm, and significant disease of other valves. The purpose of the study was to determine the freedom from NYHA III/IV symptoms and aortic valve replacement (AVR).
    Results. We identified… More >

  • Open Access


    Patient-Specific Computational Approach for Trans Catheter Aortic Valve Replacement (TAVR): Pre-Procedural Planning for Enhancing Performance and Clinical Outcomes

    Ram P. Ghosh1, Matteo Bianchi1, Gil Marom2, Oren M. Rotman1, Brandon Kovarovic1, Danny Bluestein1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 12-14, 2019, DOI:10.32604/mcb.2019.07379

    Abstract This article has no abstract. More >

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