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Bicuspid and Unicuspid Aortic Valve: Fate of Moderate/Severe Mixed Aortic Valve Disease

Alexander C. Egbe*, Heidi M. Connolly*, Joseph T. Poterucha*,†, Carole A. Warnes*

Divisions of *Cardiovascular Diseases and †Pediatric Cardiology, Mayo Clinic Rochester, Minn, USA

* Corresponding Author: Carole A. Warnes. email; Mayo Clin, Div Cardiovasc Dis, 200 First St SW, Rochester, MN 55905 USA.

Congenital Heart Disease 2017, 12(1), 24-31.

Abstract

Objectives. There is a paucity of data about mixed aortic valve disease (MAVD) in patients with bicuspid/unicuspid aortic valve (BAV). This study sought to describe the outcomes of patients with moderate/severe MAVD.
Methods. We queried our database for patients with BAV and moderate/severe MAVD seen between 1994 and 2013. We excluded patients with baseline New York Heart Association (NYHA) III/IV symptoms, left ventricular ejection fraction <50%, aortic dimension >50 mm, and significant disease of other valves. The purpose of the study was to determine the freedom from NYHA III/IV symptoms and aortic valve replacement (AVR).
Results. We identified 138 patients with moderate/severe MAVD; mean age was 51 ± 12 years; 112 (81%) were males; and follow-up was 8.5 ± 4 years. Ninety-two patients (67%) underwent AVR within 3.7 ± 2.5 years. Mechanical prostheses were implanted in 73 patients (79%); 22 patients (26%) and 36 patients (39%) had concomitant coronary artery bypass graft and aorta replacement during AVR respectively. There were no surgical deaths. Freedom from AVR was 84%, 51%, and 20% at 1, 5 and 10 years respectively. Predictors of AVR were age at presentation (hazard ratio [HR] 5.22; confidence interval [CI] 3.10 to 6.64) for every decade increase in age; and having severe stenosis or regurgitation at the time of presentation (HR 1.32; CI 1.05 to 3.16).
Conclusions. Age and disease severity should be incorporated in the risk assessment of BAV patients with MAVD, and patients with both risk factors should be monitored closely.

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Cite This Article

APA Style
Egbe, A.C., Connolly, H.M., Poterucha, J.T., Warnes, C.A. (2017). Bicuspid and unicuspid aortic valve: fate of moderate/severe mixed aortic valve disease. Congenital Heart Disease, 12(1), 24-31.
Vancouver Style
Egbe AC, Connolly HM, Poterucha JT, Warnes CA. Bicuspid and unicuspid aortic valve: fate of moderate/severe mixed aortic valve disease. Congeni Heart Dis. 2017;12(1):24-31
IEEE Style
A.C. Egbe, H.M. Connolly, J.T. Poterucha, and C.A. Warnes "Bicuspid and Unicuspid Aortic Valve: Fate of Moderate/Severe Mixed Aortic Valve Disease," Congeni. Heart Dis., vol. 12, no. 1, pp. 24-31. 2017.



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