Binbin QIAN1, Xiaoduo LIU2, Xiaolin GU1, Lu YANG3, Dake CHEN1,*
BIOCELL, Vol.44, No.1, pp. 19-26, 2020, DOI:10.32604/biocell.2020.07859
Abstract Prolylcarboxypeptidase (PRCP) belongs to the S28 family of proteases, which is also a dipeptidyl peptidase.
In this study, we demonstrate the expression pattern of PRCP in Non-small cell lung cancer (NSCLC). We found that
the repression of PRCP expression by small interfering RNA successfully inhibited cell proliferation, migration, and
invasion. Further, we explored the involvement of PRCP in the regulation of epithelial-mesenchymal transition (EMT).
The epithelial marker E-cadherin was significantly increased, meanwhile mesenchymal markers MUC1, vimentin, and
SNAIL were markedly decreased in PRCP knockdown cells. Moreover, the downregulation of PRCP in the NSCLC
cells induced the expression of apoptosis-related proteins… More >
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