Guoliang Zhong¹, Tianqing Yang¹, Shuqi Lin¹, Muyi Zhong^1,2,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.076300 - 21 May 2026

Abstract Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2-negative (HR+/HER2−) breast cancer treatment has made a breakthrough due to the introduction of cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors. This article mainly reviews the mechanisms of action, clinical efficacy, and current application status of CDK4/6 inhibitors, including Palbociclib, Ribociclib, Abemaciclib, and the emerging Dalpiciclib. The advantages and limitations of different treatment stages are also discussed. CDK4/6 inhibitors have excellent efficacy in prolonging progression-free survival (PFS) and overall survival (OS), and have become a key option for HR+/HER2− breast cancer first-line and adjuvant treatment. The issues of drug More >

Ji Hoon Jang, Joo-Young Kim, Tae-Jin Lee^*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.073660 - 21 May 2026

Abstract Molecular glue degraders (MGDs) are an emerging class of small molecules that promote selective protein degradation by inducing neomorphic interactions between E3 ubiquitin ligases and non-native substrates, referred to as neosubstrates. Clinically validated examples include thalidomide analogs that recruit cereblon (CRBN) to degrade IKAROS family zinc finger 1/3 in multiple myeloma, and arylsulfonamide-based MGDs that promote the degradation of RNA-binding protein 39 in acute myeloid leukemia and solid tumors. These molecules highlight the therapeutic potential of this modality in oncology. These findings underscore the promise of MGDs for eliminating oncogenic proteins previously considered undruggable and… More > Graphic Abstract

Zheng Yang¹, Hua Zhu^1,*, Zhao Li², Gang Wang³, Meng Su¹

Journal of Cyber Security, Vol.8, pp. 189-210, 2026, DOI:10.32604/jcs.2026.078232 - 18 May 2026

Abstract The rapid integration of IoT technologies in modern power systems, while enhancing operational efficiency, has introduced critical cybersecurity vulnerabilities. The proliferation of interconnected terminal devices across diverse operational domains has escalated cybersecurity risks, particularly from sophisticated malware attacks targeting critical grid infrastructure. These threats manifest through Application Programming Interface (API) call hijacking, command injection in industrial control protocols, and evasion of conventional signature-based detection systems. To address these challenges, this paper proposes a novel malware detection framework specifically designed for power IoT ecosystems. First, a malware detection model based on long short-term memory network (LSTM)… More >

Abdullah Alariyan¹, Abdulhadi Alzabout², Mohammed Alariyan³, Anas Alaryan⁴, Mahmoud Alhashash⁵, Abdulrahman Ahmed⁶, Mohammed Abdulaal⁷, Ahed Habib^8,*

Structural Durability & Health Monitoring, Vol.20, No.3, 2026, DOI:10.32604/sdhm.2026.076012 - 18 May 2026

Abstract Unsupervised machine learning has recently gained attention in structural health monitoring as engineers seek methods that can interpret large and complex data sets without prior labeling. Traditional diagnostic approaches often rely on predefined models or manual analysis, which limits their adaptability and efficiency when dealing with evolving structural behaviors or unforeseen conditions. Despite the growing interest in this domain, the literature remains fragmented, with limited systematic and bibliometric reviews that consolidate progress, identify prevailing trends, and clarify methodological limitations. This study addresses this gap through a comprehensive systematic and bibliometric review of research on unsupervised More >

Shan Yuan^1,2, Fei Wang^2,*, Jinping Zhang^2,*, Yuxin Jiang², Kaibo Gu², Chenhao Qiao², Yutong Bai², Jie Yu², Quan Chen¹, Dedi Han³

Chalcogenide Letters, Vol.23, No.4, 2026, DOI:10.32604/cl.2026.082805 - 09 May 2026

Abstract Sodium metal batteries stand as a highly promising electrochemical energy storage system; however, their commercialization is severely impeded by challenges such as anode dendrite formation, the shuttle effect of highly reactive intermediates at the cathode, electrode volume expansion, and interfacial instability. Owing to their high electronic conductivity, high theoretical specific capacity, and superior sodiumphilic affinity, tellurium and its tellurides have emerged as pivotal functional materials for enhancing the performance of sodium metal batteries. This study reviews the advancements in their applications within sodium metal batteries, elaborates rational design strategies carbon-based composites, alloying, and heterostructure construction More >

Bushra A. Hasan¹, Ameer J. Fadhl², Ahmad A. Hasan¹, Yasser A. Jebbar^3,*

Chalcogenide Letters, Vol.23, No.4, 2026, DOI:10.32604/cl.2026.079634 - 09 May 2026

Abstract Copper zinc tin sulfide selenide, Cu₂ZnSn(S_1−xSe_x)₄, absorbers are promising earth-abundant and environmentally benign materials for low-cost photovoltaic applications. This study investigates the structural and optical properties of Cu₂ZnSn(S_1−xSe_x)₄ nanostructured thin films prepared by pulsed laser deposition using melt-quenched targets with selenium compositions x = 0.0–1.0. X-ray diffraction revealed that films with low selenium content remained amorphous, whereas higher selenium incorporation promoted the formation of polycrystalline kesterite–stannite phases with preferred orientations along (112), (200), (220), and (312). The crystallite size increased from 12.3 to 17.9 nm as selenium reached x = 1.0, indicating enhanced crystal growth. Atomic force… More >

Walaa Alayed¹, Asad Ur Rehman², M.Awais Ehsan³, Waqar Ul Hassan⁴, Ahmed Zeeshan^5,6,*

CMC-Computers, Materials & Continua, Vol.88, No.1, 2026, DOI:10.32604/cmc.2026.078078 - 08 May 2026

Abstract The rapid growth in the field of data and cloud computing has made it essential to ensure information security. Encryption consists of multiple layers, among which a critical component is the Substitution box (S-box). The S-box provides nonlinearity and confusion between the original and cipher forms, and its performance directly determines the security of the cipher against cryptanalysis. Chaotic systems have been widely used for image encryption, however, they suffer from well known limitations such as deterministic periodicity and reduced unpredictability in finite field digital environments. To address these issues, we propose a new S-box… More >

Yutong Guo^1,2, Jianying Yang^1,3, Chao Yang^1,3,*

CMC-Computers, Materials & Continua, Vol.88, No.1, 2026, DOI:10.32604/cmc.2026.077820 - 08 May 2026

Abstract Large language models (LLMs) and related foundation-model workflows are emerging as promising tools for advancing foundry intelligence across the casting value chain. This review examines their applications in material design and property prediction, process parameter optimization and intelligent control, and defect detection and quality tracing in casting environments. The surveyed studies indicate that LLM-enabled systems can help integrate unstructured technical knowledge with multimodal industrial data. This integration supports composition design, simulation-assisted process optimization, diagnostic reasoning, and knowledge-grounded decision support. However, current evidence shows that the transition from pilot demonstrations to robust industrial deployment remains constrained More >

Haoran Li, Qi Sun, Haoran Sun, Ziyan Wu, Wenjin Wang, Fang Liu^*

Phyton-International Journal of Experimental Botany, Vol.95, No.4, 2026, DOI:10.32604/phyton.2026.079359 - 28 April 2026

Abstract Soil salinization is an increasingly severe global issue, posing a significant threat to crop growth and food security. Although sorghum exhibits moderate tolerance to saline-alkali stress, it remains highly sensitive to such conditions during the seedling stage. This study investigates the mechanisms by which zinc oxide nanoparticles (ZnO NPs) alleviate saline-alkali stress in sorghum seedlings and determines their optimal application concentration, thereby providing a scientific basis for agricultural production in saline-alkali soils. Hydroponic experiments were conducted to simulate varying degrees of saline-alkali stress. Sorghum seedlings were treated with different concentrations of ZnO NPs (0, 50,… More >

Selma Kösa^*

Phyton-International Journal of Experimental Botany, Vol.95, No.4, 2026, DOI:10.32604/phyton.2026.079055 - 28 April 2026

Abstract This study was conducted to determine the effects of paclobutrazol (PBZ) application methods and dosages on the growth, leaf, flower, and color characteristics of Silene compacta Fisch., a natural species with high potential for use as a seasonal bedding and potted ornamental plant in landscape design. The experiment was carried out under greenhouse conditions, where potted plants received a single PBZ application during the vegetative stage. The study was arranged in a completely randomized design with a 2 × 3 factorial structure. PBZ was applied either as a foliar spray or as a soil drench at… More >