ZHAOHUI HU1,2, XIANGJUN DING3, YUYAO JI2, XIAOHONG LIU4,*, ZHIWEN DING2,*
BIOCELL, Vol.45, No.3, pp. 745-749, 2021, DOI:10.32604/biocell.2021.013293
Abstract Apurine/pyrimidine-free endonuclease 1 (APEX1) is a multifunctional enzyme that contributes to oxidizationmediated DNA-cleaved base excision repair and redox activation of transcription factors. However, the role of APEX1
during cardiomyocyte oxidative stress injury is not completely understood. In the present study, whether
APEX1 protects oxidative damage-induced cardiomyocytes was investigated. mRNA and protein expression levels of
APEX1 were downregulated in the mouse model of cardiac ischemia-reperfusion injury. Furthermore, the expression
of APEX1 in hydrogen peroxide (H2O2)-treated neonatal mice cardiomyocytes was also decreased. APEX1 knockdown
aggravated H2O2-treated cardiomyocyte apoptosis indexes. By contrast, APEX1 overexpression reversed H2O2-induced
oxidative damage, as demonstrated by decreased caspase… More >
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