Marc Dubourdeau1,2, Gérald Chêne1, Agnès Coste1, José Bernad1, Jean-Claude Lepert1, Claudine Orfila1, Bernard Pipy1, Denis Rousseau3
European Cytokine Network, Vol.19, No.4, pp. 156-165, 2008, DOI:10.1684/ecn.2008.0134
Abstract The cyclin kinase inhibitor p21WAF1
is expressed in most, if not all, differentiated cells in the
human body and represents an important regulator of cell cycle control and terminal differentiation in the
monocyte/macrophage lineage. It has been reported in macrophage cell lines that p21WAF1 expression is sensi-tive
to numerous molecules including cytokines, but nothing was known about p21WAF1 regulation in human
peripheral blood monocytes in response to Th2 cytokines. We report here, that IL-13 increases p21WAF1 expres-sion
in human blood monocytes. This induction is a transcription-dependent event, leading to an increase in
mRNA content. We show that… More >
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