E. Shaik∗, K.A. Hoffmann∗, J-F. Dietiker∗
Molecular & Cellular Biomechanics, Vol.4, No.1, pp. 41-54, 2007, DOI:10.3970/mcb.2007.004.041
Abstract A potential interaction between the local hemodynamics and the artery wall response has been suggested for vascular graft failure by intimal hyperplasia (IH). Among the various hemodynamic factors, wall shear stress has been implicated as the primary factor responsible for the development of IH. In order to explore the role of hemodynamics in the formation of IH in end-to-side anastomosis, computational fluid dynamics is employed. To validate the numerical simulations, comparisons with existing experimental data are performed for both steady and pulsatile flows. Generally, good agreement is observed with the velocity profiles whereas some discrepancies are found in wall shear… More >
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