Vijay L. KUMAR1 *, B. GURUPRASAD1, Priyanka CHAUDHARY2
BIOCELL, Vol.38, No.1, pp. 1-6, 2014, DOI:10.32604/biocell.2014.38.001
Abstract Artesunate, an antimalarial drug, has been shown to inhibit the release of inflammatory mediators
in various disease conditions. The present study was carried out to evaluate the anti-edematogenic effect of artesunate in the rat paw edema model. Inflammation was induced in the hind paw of rat by sub-plantar injection of
0.1 mL of 0.5% carrageenan and the paw volume was measured up to a fixed mark just before the injection and
then after 3 h. The difference in two volumes gave a measure of edema formation. At 3h the level of TNF-α, PGE2
and myeloperoxidase were estimated in the inflamed… More >
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