BICHUN ZHAO1, XUEQING WU2,*, YITONG YUAN1, YUANTAO GAO1, XIAO LI2, RUOCHEN DU1, SUMING XU2, RUXIN ZHANG1, CHUNFANG WANG1,*
BIOCELL, Vol.44, No.4, pp. 487-499, 2020, DOI:10.32604/biocell.2020.011638
Abstract In vitro maturation (IVM), a promising assisted reproductive technology (ART), has been evolving in clinical
trials and applications. There is a huge potential demand for IVM in clinical practice because it reduces the stimulation of
gonadotropins to patients and provides evidence for the safety of neonatal birth. Unfortunately, the maturation rate of
oocytes in vivo is not as high as it is in vivo due to a different microenvironment. Moreover, there are still
controversies in predicting the developmental capability of oocytes in IVM. The granulosa cells (GCs) and cumulus
cells (CCs), closely surrounding the oocytes, play a critical role in… More >
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