Liwei Jia*, Dongying Lv†, Shuang Zhang*, Zhenyue Wang*, Bo Zhou*
Oncology Research, Vol.27, No.4, pp. 503-508, 2019, DOI:10.3727/096504018X15344989701565
Abstract Astragaloside IV (AS-IV) is an active ingredient in Astragalus membranaceus and is involved in various
biological processes, such as regulating the immune system, and counteracting inflammation and malignancy.
The aim of this study was to explore the effect of AS-IV on non-small cell lung cancer (NSCLC) cells. Cell
counting kit (CCK)-8 assay and flow cytometry were performed to investigate cell survival and cell death, and
Western blotting was performed to assess protein expression. We found that AS-IV inhibited the migration
and proliferation of NSCLC cells and caused a noticeable increase in cell death. Furthermore, the expression
of Bax, a marker… More >
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