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  • Open Access


    Atrial Septal Defect in Children: The Incidence and Risk Factors for Diagnosis

    Gustaf Tanghöj1,*, Anna Lindam2, Petru Liuba3,4, Gunnar Sjöberg5, Estelle Naumburg1

    Congenital Heart Disease, Vol.15, No.5, pp. 287-299, 2020, DOI:10.32604/CHD.2020.011977

    Abstract Objective: Secundum atrial septal defect (ASD II) is a common congenital heart defect, and interatrial communications among preterm children is even more common. The objective of this study was to calculate the incidence of ASD II in children, with assessment to gestational age at birth. Further, to assess maternal, prenatal and postnatal risk factors associated with ASD II among children of different gestational age at birth. Design: This national registry based retrospective incidence study was supplemented with a national case-control study, using the Swedish Register of Congenial Heart Disease, Swedish Medical Birth Register and Statistics Sweden. All children, 0–18 years… More >

  • Open Access


    Successful Percutaneous Closure of Atrial Septal Defect via Transjugular Approach with the Cocoon Septal Occluder

    Maria Drakopoulou1, George Oikonomou1, Stergios Soulaidopoulos1, Basil Thanopoulos2, Konstantina Aggeli1, Dimitrios Tousoulis1, Konstantinos Toutouzas1,*

    Congenital Heart Disease, Vol.15, No.3, pp. 147-151, 2020, DOI:10.32604/CHD.2020.011338

    Abstract The percutaneous closure of ostium secundum atrial septal defects (ASD) is a well-established procedure. Currently available devices and delivery systems are designed to be used via the femoral venous route. However, an alternative approach needs to be considered in cases of congenital or acquired caval obstruction. We describe a successful transjugular closure of a moderate sized secundum ASD with the Cocoon Septal Occluder in a 37-year-old symptomatic woman with inferior vena cava (IVC) thrombosis, using a novel deployment technique to overcome difficulties, namely maintaining stable sheath position in the left atrium. Percutaneous closure of secundum ASDs via the transjugular approach… More >

  • Open Access


    Safety and Efficacy of Transcatheter Closure of Atrial Septal Defects in Everyday Practice. A Multicenter Study in a Developing Country

    Amira Nour1,*, Heba Kamel1, Yasmeen Abdelrazik1, Khaled Shams2, Noha Gamal3, Safaa Huessin4, Alaa Roushdy1, Maiy El Sayed1

    Congenital Heart Disease, Vol.15, No.2, pp. 79-87, 2020, DOI:10.32604/CHD.2020.011249

    Abstract Background: Transcatheter closure of secudum atrial septal defect (ASD) has gained wide acceptance since its introduction more than 3 decades ago. Safety and efficacy of the procedure in everyday practice needs continuous update. Objective: The aim of the study is to determine the incidence of complications and identify everyday management protocols. Methods: This is a prospective nonrandomized study including all the patients with Secundum ASD or fenestrated IAS referred to two different congenital heart diseases centers in Ain Shams university and sohag university in Egypt over 2 years with an indication for closure according to American and European guidelines. A… More >

  • Open Access


    Cardiac Troponin Levels after Percutaneous Atrial Septal Defect Closure: A Qualitative Systematic Review and Meta-Analysis

    Alejandro E. Contreras1,*, Alejandro R. Peirone2, Eduardo Cuestas3

    Congenital Heart Disease, Vol.15, No.1, pp. 13-20, 2020, DOI:10.32604/CHD.2020.011575

    Abstract Introduction: We conducted a systematic review and meta-analysis of published studies to determine the prevalence of troponin elevation after percutaneous atrial septal defect closure (pASDc) as well as to describe the association between troponin elevation and different anatomical risk factors for erosion. Methods: A qualitative systematic review and meta-analysis was undertaken. The selected studies included patients of any age receiving a pASDc; performed under transesophageal echocardiography monitoring; reporting troponin level measurement after the intervention; and indicating prevalence of troponin elevation and/or the association with risk factors for erosion. Results: Six studies were found which included 391 patients in total. The… More >

  • Open Access


    Hemodynamic, biological, and right ventricular functional changes following intraatrial shunt repair in patients with flow-induced pulmonary hypertension

    Chih-Hsin Hsu1,2, Jun-Neng Roan1,3, Jieh-Neng Wang4, Chien-Chi Huang5, Chao-Jung Shih3, Jyh-Hong Chen2,6, Jing-Ming Wu4, Chen-Fuh Lam7,8

    Congenital Heart Disease, Vol.12, No.4, pp. 533-539, 2017, DOI:10.1111/chd.12479

    Abstract Objectives: Atrial septal defects may result in pulmonary hypertension and right heart remodeling. We analyzed improvements in patients with flow-induced pulmonary hypertension and the activation of endothelial progenitor cells after flow reduction.
    Design: This prospective cohort study included 37 patients who were admitted for an occluder implantation. Blood samples were collected before and after the procedure. We determined the number of endothelial progenitor cells in outgrowth colonies and serum Hsp27 concentrations. Daily performance and cardiothoracic ratio were reevaluated later.
    Results: Closure of the defect significantly reduced the pulmonary pressure and B-type natriuretic peptide levels. The cardiothoracic ratio and daily performance… More >

  • Open Access


    Atrial septal defect in adults is associated with airway hyperresponsiveness

    Martina Nassif1, Reindert P. van Steenwijk2, Jacqueline M. Hogenhout2, Huangling Lu1, Rianne H.A.C.M. de Bruin‐Bon B Health1, Alexander Hirsch1,3, Peter J. Sterk MD, PhD2 | Berto J. Bouma MD, PhD1 | Bart Straver MD, PhD4 | Jan G.P. Tijssen1, Barbara J.M. Mulder1,5, Robbert J. de Winter1

    Congenital Heart Disease, Vol.13, No.6, pp. 959-966, 2018, DOI:10.1111/chd.12665

    Abstract Objective: The association between secundum atrial septal defects (ASD) and asthma‐ like dyspnea with consequent long‐term pulmonary inhalant use, is poorly understood in adult ASD patients. Airway hyperresponsiveness is suggested to be the underlying mechanism of cardiac asthma from mitral valve disease and ischemic cardiomyopathy. We hypothesized that airway hyperresponsiveness may also be found in adult ASD patients. Our aim was to study airway responsiveness in adult ASD patients before percutaneous closure and at short‐and long‐term postprocedural follow‐up.
    Methods: This prospective study included 31 ASD patients (65% female, mean age 49 ± 15y) who underwent spirometry and bronchoprovocation testing pre‐and… More >

  • Open Access


    The 745.5 issue in code-based, adult congenital heart disease population studies: Relevance to current and future ICD-9-CM and ICD-10-CM studies

    Fred H. Rodriguez III1,2,3,4, Georges Ephrem1,2, Jennifer F. Gerardin1,2, Cheryl Raskind-Hood5, Carol Hogue5, Wendy Book1,2

    Congenital Heart Disease, Vol.13, No.1, pp. 59-64, 2018, DOI:10.1111/chd.12563

    Abstract Objective: Although the ICD-9-CM code 745.5 is widely used to indicate the presence of a secundum atrial septal defect (ASD), it is also used for patent foramen ovale (PFO) which is a normal variant and for “rule-out” congenital heart disease (CHD). The ICD-10-CM code Q21.1 perpetuates this issue. The objective of this study was to assess whether code 745.5 in isolation or in combination with unspecified CHD codes 746.9 or 746.89 miscodes for CHD, and if true CHD positives decrease with age.
    Design: Echocardiograms of patients with an ICD-9-CM code of 745.5 in isolation or in combination with unspecified CHD… More >

  • Open Access


    Time course of the changes in right and left ventricle function and associated factors after transcatheter closure of atrial septal defects

    Byung W. Yoo1, Jung O. Kim2, Lucy Y. Eun2, Jae Y. Choi2, Dong S. Kim3

    Congenital Heart Disease, Vol.13, No.1, pp. 131-139, 2018, DOI:10.1111/chd.12541

    Abstract Objective: The purpose of this study was to evaluate the changes in right ventricle (RV) and left ventricle (LV) function after transcatheter atrial septal defect (ASD) closure and to assess the influence of the age and the amount of shunt.
    Design: Retrospective study
    Patients: Fifty-three adult patients who underwent transcatheter closure were enrolled, then divided into subgroups according to the age (< 40 years vs ≥ 40 years), and the amount of shunt flow (QpQs < 2.5 vs QpQs ≥ 2.5).
    Outcome Measures: Two-dimensional tissue Doppler imaging was performed in a four-chamber view at the basal ventricular septum (VS) and… More >

  • Open Access


    Concomitant pulmonary vein isolation and percutaneous closure of atrial septal defects: A pilot project

    Reinder Evertz1, Charlotte A. Houck2, Tim ten Cate1, Anthonie L. Duijnhouwer1, Rypko Beukema1, Sjoerd Westra1, Kevin Vernooy 1,3, Natasja M. S. de Groot2

    Congenital Heart Disease, Vol.14, No.6, pp. 1123-1129, 2019, DOI:10.1111/chd.12859

    Abstract Background: Patients with an atrial septal defect (ASD) are at increased risk of de‐ veloping atrial fibrillation (AF). Currently percutaneous ASD closure is the preferred therapeutic strategy and although pulmonary vein isolation (PVI) for AF is feasible after ASD closure, the transseptal puncture can be technically challenging and prob‐ ably increases the perioperative risk. A staged approach, with PVI several months be‐ fore ASD closure, has been recommended for patients already scheduled for closure, but no data are available on combined procedures.
    Purpose: This pilot study evaluates the feasibility of a combined procedure of PVI and ASD closure in patients… More >

  • Open Access


    Immediate and short‐term effects of transcatheter device closure of large atrial septal defect in senior people

    Shihai Wang, Jun’an Pan, Bei Xiao, Yongjiang Tang, Jianjun Lan, Xuezhong Zheng, Chao Yang, Dawen Xu, Jiyu Zhang

    Congenital Heart Disease, Vol.14, No.6, pp. 939-944, 2019, DOI:10.1111/chd.12844

    Abstract Objectives: We sought to evaluate the safety and efficacy in improving cardiac function and functional capacity with device closure of large atrial septal defects (ASD) in senior adults.
    Background: Atrial septal defect accounts for about 10% of all congenital heart dis‐ ease. It still remains unclear whether large ASD closure in senior people should be performed or not. Hence we aim to prospectively assess the safety and clinical status of senior patients after transcatheter closure in large ASD.
    Patients and interventions: This was a prospective study of all patients aged over 50 years who underwent device closure of a secundum… More >

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