Biagio Castaldi^1,*, Giulio Cabrelle¹, Massimo Padalino², Vladimiro Vida², Ornella Milanesi¹, Giovanni Di Salvo¹

Congenital Heart Disease, Vol.15, No.5, pp. 347-360, 2020, DOI:10.32604/CHD.2020.012750

Abstract Background: Trans-catheter closure has become the treatment of choice for patent foramen ovale (PFO) and ostium secundum atrial septal defects (ASD). A wide variety of devices are commercially available, however, concerns have been raised about the risk of cardiac erosion associated with stiff/rigid devices. The GORE® CARDIOFORM Septal Occluder (GSO) is a double-disc, soft and conformable device with no reported incidence of cardiac erosions. However, wire frame fracture (WFF) have been reported. Aim: To assess the incidence and clinical significance of WFF after GSO implantation in paediatric patients. Methods: Seventy-seven consecutive patients were enrolled. Periprocedural and follow-up assessments included clinical,… More >

Gustaf Tanghöj^1,*, Anna Lindam², Petru Liuba^3,4, Gunnar Sjöberg⁵, Estelle Naumburg¹

Congenital Heart Disease, Vol.15, No.5, pp. 287-299, 2020, DOI:10.32604/CHD.2020.011977

Abstract Objective: Secundum atrial septal defect (ASD II) is a common congenital heart defect, and interatrial communications among preterm children is even more common. The objective of this study was to calculate the incidence of ASD II in children, with assessment to gestational age at birth. Further, to assess maternal, prenatal and postnatal risk factors associated with ASD II among children of different gestational age at birth. Design: This national registry based retrospective incidence study was supplemented with a national case-control study, using the Swedish Register of Congenial Heart Disease, Swedish Medical Birth Register and Statistics Sweden. All children, 0–18 years… More >

Maria Drakopoulou¹, George Oikonomou¹, Stergios Soulaidopoulos¹, Basil Thanopoulos², Konstantina Aggeli¹, Dimitrios Tousoulis¹, Konstantinos Toutouzas^1,*

Congenital Heart Disease, Vol.15, No.3, pp. 147-151, 2020, DOI:10.32604/CHD.2020.011338

Abstract The percutaneous closure of ostium secundum atrial septal defects (ASD) is a well-established procedure. Currently available devices and delivery systems are designed to be used via the femoral venous route. However, an alternative approach needs to be considered in cases of congenital or acquired caval obstruction. We describe a successful transjugular closure of a moderate sized secundum ASD with the Cocoon Septal Occluder in a 37-year-old symptomatic woman with inferior vena cava (IVC) thrombosis, using a novel deployment technique to overcome difficulties, namely maintaining stable sheath position in the left atrium. Percutaneous closure of secundum ASDs via the transjugular approach… More >

Amira Nour^1,*, Heba Kamel¹, Yasmeen Abdelrazik¹, Khaled Shams², Noha Gamal³, Safaa Huessin⁴, Alaa Roushdy¹, Maiy El Sayed¹

Congenital Heart Disease, Vol.15, No.2, pp. 79-87, 2020, DOI:10.32604/CHD.2020.011249

Abstract Background: Transcatheter closure of secudum atrial septal defect (ASD) has gained wide acceptance since its introduction more than 3 decades ago. Safety and efficacy of the procedure in everyday practice needs continuous update. Objective: The aim of the study is to determine the incidence of complications and identify everyday management protocols. Methods: This is a prospective nonrandomized study including all the patients with Secundum ASD or fenestrated IAS referred to two different congenital heart diseases centers in Ain Shams university and sohag university in Egypt over 2 years with an indication for closure according to American and European guidelines. A… More >

Alejandro E. Contreras^1,*, Alejandro R. Peirone², Eduardo Cuestas³

Congenital Heart Disease, Vol.15, No.1, pp. 13-20, 2020, DOI:10.32604/CHD.2020.011575

Abstract Introduction: We conducted a systematic review and meta-analysis of published studies to determine the prevalence of troponin elevation after percutaneous atrial septal defect closure (pASDc) as well as to describe the association between troponin elevation and different anatomical risk factors for erosion. Methods: A qualitative systematic review and meta-analysis was undertaken. The selected studies included patients of any age receiving a pASDc; performed under transesophageal echocardiography monitoring; reporting troponin level measurement after the intervention; and indicating prevalence of troponin elevation and/or the association with risk factors for erosion. Results: Six studies were found which included 391 patients in total. The… More >

Chih-Hsin Hsu^1,2, Jun-Neng Roan^1,3, Jieh-Neng Wang⁴, Chien-Chi Huang⁵, Chao-Jung Shih³, Jyh-Hong Chen^2,6, Jing-Ming Wu⁴, Chen-Fuh Lam^7,8

Congenital Heart Disease, Vol.12, No.4, pp. 533-539, 2017, DOI:10.1111/chd.12479

Abstract Objectives: Atrial septal defects may result in pulmonary hypertension and right heart remodeling. We analyzed improvements in patients with flow-induced pulmonary hypertension and the activation of endothelial progenitor cells after flow reduction.
Design: This prospective cohort study included 37 patients who were admitted for an occluder implantation. Blood samples were collected before and after the procedure. We determined the number of endothelial progenitor cells in outgrowth colonies and serum Hsp27 concentrations. Daily performance and cardiothoracic ratio were reevaluated later.
Results: Closure of the defect significantly reduced the pulmonary pressure and B-type natriuretic peptide levels. The cardiothoracic ratio and daily performance… More >

Martina Nassif¹, Reindert P. van Steenwijk², Jacqueline M. Hogenhout², Huangling Lu¹, Rianne H.A.C.M. de Bruin‐Bon B Health¹, Alexander Hirsch^1,3, Peter J. Sterk MD, PhD2 | Berto J. Bouma MD, PhD1 | Bart Straver MD, PhD4 | Jan G.P. Tijssen¹, Barbara J.M. Mulder^1,5, Robbert J. de Winter¹

Congenital Heart Disease, Vol.13, No.6, pp. 959-966, 2018, DOI:10.1111/chd.12665

Abstract Objective: The association between secundum atrial septal defects (ASD) and asthma‐ like dyspnea with consequent long‐term pulmonary inhalant use, is poorly understood in adult ASD patients. Airway hyperresponsiveness is suggested to be the underlying mechanism of cardiac asthma from mitral valve disease and ischemic cardiomyopathy. We hypothesized that airway hyperresponsiveness may also be found in adult ASD patients. Our aim was to study airway responsiveness in adult ASD patients before percutaneous closure and at short‐and long‐term postprocedural follow‐up.
Methods: This prospective study included 31 ASD patients (65% female, mean age 49 ± 15y) who underwent spirometry and bronchoprovocation testing pre‐and… More >

Fred H. Rodriguez III^1,2,3,4, Georges Ephrem^1,2, Jennifer F. Gerardin^1,2, Cheryl Raskind-Hood⁵, Carol Hogue⁵, Wendy Book^1,2

Congenital Heart Disease, Vol.13, No.1, pp. 59-64, 2018, DOI:10.1111/chd.12563

Abstract Objective: Although the ICD-9-CM code 745.5 is widely used to indicate the presence of a secundum atrial septal defect (ASD), it is also used for patent foramen ovale (PFO) which is a normal variant and for “rule-out” congenital heart disease (CHD). The ICD-10-CM code Q21.1 perpetuates this issue. The objective of this study was to assess whether code 745.5 in isolation or in combination with unspecified CHD codes 746.9 or 746.89 miscodes for CHD, and if true CHD positives decrease with age.
Design: Echocardiograms of patients with an ICD-9-CM code of 745.5 in isolation or in combination with unspecified CHD… More >

Byung W. Yoo¹, Jung O. Kim², Lucy Y. Eun², Jae Y. Choi², Dong S. Kim³

Congenital Heart Disease, Vol.13, No.1, pp. 131-139, 2018, DOI:10.1111/chd.12541

Abstract Objective: The purpose of this study was to evaluate the changes in right ventricle (RV) and left ventricle (LV) function after transcatheter atrial septal defect (ASD) closure and to assess the influence of the age and the amount of shunt.
Design: Retrospective study
Patients: Fifty-three adult patients who underwent transcatheter closure were enrolled, then divided into subgroups according to the age (< 40 years vs ≥ 40 years), and the amount of shunt flow (QpQs < 2.5 vs QpQs ≥ 2.5).
Outcome Measures: Two-dimensional tissue Doppler imaging was performed in a four-chamber view at the basal ventricular septum (VS) and… More >

Reinder Evertz¹, Charlotte A. Houck², Tim ten Cate¹, Anthonie L. Duijnhouwer¹, Rypko Beukema¹, Sjoerd Westra¹, Kevin Vernooy ^1,3, Natasja M. S. de Groot²

Congenital Heart Disease, Vol.14, No.6, pp. 1123-1129, 2019, DOI:10.1111/chd.12859

Abstract Background: Patients with an atrial septal defect (ASD) are at increased risk of de‐ veloping atrial fibrillation (AF). Currently percutaneous ASD closure is the preferred therapeutic strategy and although pulmonary vein isolation (PVI) for AF is feasible after ASD closure, the transseptal puncture can be technically challenging and prob‐ ably increases the perioperative risk. A staged approach, with PVI several months be‐ fore ASD closure, has been recommended for patients already scheduled for closure, but no data are available on combined procedures.
Purpose: This pilot study evaluates the feasibility of a combined procedure of PVI and ASD closure in patients… More >