Uma Ramasamy^*, Sundar Santhoshkumar

Journal of Intelligent Medicine and Healthcare, Vol.2, pp. 1-14, 2024, DOI:10.32604/jimh.2023.046995 - 10 January 2024

Abstract More than 140 autoimmune diseases have distinct autoantibodies and symptoms, and it makes it challenging to construct an appropriate model using Machine Learning (ML) for autoimmune disease. Arthritis-related autoimmunity requires special attention. Although many conventional biomarkers for arthritis have been established, more biomarkers of arthritis autoimmune diseases remain to be identified. This review focuses on the research conducted using data obtained from clinical laboratory testing of real-time arthritis patients. The collected data is labelled the Arthritis Profile Data (APD) dataset. The APD dataset is the retrospective data with many missing values. We undertook a comprehensive… More >

Mohammad Reza Haghshenas¹, Mina Roshan Zamir¹, Mahboubeh Sadeghi¹, Mohammad Javad Fattahi¹, Kimia Mirshekari¹, Abbas Ghaderi^1,2,*

European Cytokine Network, Vol.33, No.3, pp. 54-69, 2022, DOI:10.1684/ecn.2022.0480

Abstract Interleukin-38 (IL-38) is the most recent member of the IL-1 family that acts as a natural inflammatory inhibitor by binding to cognate receptors, particularly the IL-36 receptor. In vitro, animal and human studies on autoimmune, metabolic, cardiovascular and allergic diseases, as well sepsis and respiratory viral infections, have shown that IL-38 exerts an anti-inflammatory activity by modulating the generation and function of inflammatory cytokines (e.g. IL-6, IL-8, IL-17 and IL-36) and regulating dendritic cells, M2 macrophages and regulatory T cells (Tregs). Accordingly, IL-38 may possess therapeutic potential for these types of diseases. IL-38 down-regulates CCR3+… More >

Jacek Karczewski^1,4, Aleksandra Zielin´ska², Rafał Staszewski³, Piotr Eder⁴, Agnieszka Dobrowolska⁴

European Cytokine Network, Vol.32, No.4, pp. 64-72, 2021, DOI:10.1684/ecn.2021.0474

Abstract The abnormal accumulation of visceral adipose tissue in obesity is associated with metabolic changes that include altered glucose tolerance, insulin resistance, hyperlipidemia, and metabolic syndrome. Obesity also coincides with increased incidence of autoimmune diseases. Accumulating evidence suggest that prolonged metabolic overload related to overnutrition, influenced by genetic and epigenetic factors, might affect immunologic self-tolerance through changes in the energy metabolism of immune cells, particularly regulatory T (Treg) cells. A strong activation of nutrient-energy signaling pathways blocks the induction of the transcription factor forkhead P3 (FOXP3), a master regulator of Treg cells, consequently inhibiting their generation More >

Eman R. Boulis, Vikas Majithia

Canadian Journal of Urology, Vol.17, No.4, pp. 5306-5308, 2010

Abstract Testicular involvement in connective tissue diseases (CTD) is typically caused by medium vessel vasculitis as in polyarteritis nodosa. Systemic lupus erythrematosus (SLE) and systemic sclerosis cause small vessel vasculitis, which is an unusual cause of orchitis. We hereby report a case of orchitis in a 28-year-old patient caused by vasculitis related to his lupus/scleroderma overlap CTD. He had an excellent response to steroids and azathioprine with complete resolution of his testicular and systemic symptoms. Our case highlights that although testicular involvement secondary to small vessel vasculitis in CTD is uncommon, it is still possible and More >