Meng Wang*1,
Xin Wang†1,
Yuan Li‡1,
Qiang Xiao§, Xiao-Hai Cui*, Guo-Dong Xiao*, Ji-Chang Wang¶,
Chong-Wen Xu#, Hong Ren*, Dapeng Liu*
Oncology Research, Vol.27, No.9, pp. 987-995, 2019, DOI:10.3727/096504018X15424918479652
Abstract The aim of this study was to investigate the potential biological activities of nutlin-3 in the regulation of growth
and proliferation of non-small cell lung cancer (NSCLC) stem cells (CSCs), which may help in sensitizing to
axitinib-induced apoptosis. Nutlin-3 induction of p53 expression was used to test its role in controlling the
cell division pattern and apoptosis of NSCLC cells. A549 cells and H460 cells were pretreated with nutlin-3
and then treated with either an Akt1 activator or shRNA-GSK3 , to investigate the potential role of p53 sensitization in the biological effects of axitinib. We… More >
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