Benjamin S. Frank1, Tracy T. Urban2, Karlise Lewis2, Suhong Tong3, Courtney Cassidy4, Max B. Mitchell5, Christopher S. Nichols6, Jesse A. Davidson1
Congenital Heart Disease, Vol.14, No.3, pp. 446-453, 2019, DOI:10.1111/chd.12744
Abstract Objective: Patients undergoing surgical repair of aortic coarctation have a 50% risk
of pathologic left ventricular remodeling (increased left ventricular mass or relative
wall thickness). Endothelin 1, ST2, galectin 3, norepinephrine and B‐natriuretic pep‐
tide are biomarkers that have been associated with pathologic LV change in adult
populations but their predictive value following pediatric coarctation repair are not
known.
Hypothesis: Biomarker levels at coarctation repair will predict persistent left ven‐
tricular remodeling at 1‐year follow up.
Design: Prospective, cohort study of 27 patients’ age 2 days‐12 years with coarcta‐
tion of the aorta undergoing surgical repair. Echocardiograms were performed pre‐… More >
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